ArticleAJNR. American journal of neuroradiology
Pattern of cortical changes in sporadic Creutzfeldt-Jakob disease.
Article in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Diagnostic value of diffusion-weighted brain magnetic resonance imaging in patients with sporadic Creutzfeldt-Jakob disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation.JAMA neurology · 2016Trial
- High-b-value diffusion MR imaging and basal nuclei apparent diffusion coefficient measurements in variant and sporadic Creutzfeldt-Jakob disease.AJNR. American journal of neuroradiology · 2010Trial
- Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.Nature communications · 2026Article
- PRES-like MRI findings in sporadic Creutzfeldt-Jakob disease: a case report.Acta neurologica Belgica · 2026Article
- Sporadic Creutzfeldt-Jakob disease: Brain MRI lesion features from 2 cases reports.Radiology case reports · 2024Article
- Diagnostic accuracy of diffusion-weighted imaging in variant Creutzfeldt-Jakob disease.Neuroradiology · 2023Article
- Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.Human brain mapping · 2022Article
- The Use of Real-Time Quaking-Induced Conversion for the Diagnosis of Human Prion Diseases.Frontiers in aging neuroscience · 2022Review
- A rare case of Creutzfeldt-Jakob disease reported from Nepal.Clinical case reports · 2021Article
- Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt-Jakob disease.Clinical case reports · 2021Article
- The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.Nature reviews. Neurology · 2021Review
- Altered mRNA and Protein Expression of Monocarboxylate Transporter MCT1 in the Cerebral Cortex and Cerebellum of Prion Protein Knockout Mice.International journal of molecular sciences · 2021Article
- Article
- Evaluation of a New Criterion for Detecting Prion Disease With Diffusion Magnetic Resonance Imaging.JAMA neurology · 2020Article
- Article
- The worst is yet to come: probable sporadic Creutzfeldt-Jakob disease in a well-controlled HIV patient.Prion · 2019Article
- Cytoskeleton-Associated Risk Modifiers Involved in Early and Rapid Progression of Sporadic Creutzfeldt-Jakob Disease.Molecular neurobiology · 2018Article
- An In VivoMolecular neurobiology · 2018Article
- [Neurodegenerative diseases].Der Radiologe · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHigh cortical signal intensity on diffusion-weighted (DW) or fluid-attenuated inversion recovery (FLAIR) images is increasingly described in sporadic Creutzfeldt-Jakob disease (sCJD). The aim of this study was to assess the extent and location of high cortical signal intensity, to investigate whether DW or FLAIR is superior in showing changes in cortical signal intensity, and to find out whether the distribution of the signal intensity changes is random or follows a common pattern. MATERIALS AND
methodsWe analyzed FLAIR and DW MR imaging scans of 39 patients with sCJD for hyperintense cortical signal intensity. We compared the sensitivity of the DW and FLAIR scans. We correlated the extent and location of the cortical signal intensity changes with concomitant changes in deep gray matter and the genotype of codon 129 of the prion protein gene.
resultsThere was high signal intensity in the insula, the cingulate gyrus, and the superior frontal gyrus in 95%. The cortical areas near the midline also frequently showed the abnormal signal intensity (precuneus 87%, paracentral lobe 77%). The precentral and postcentral gyri were affected less frequently (41% and 28%, respectively). The DW MR imaging showed the cortical changes more effectively than FLAIR. There was no correlation between the distribution of changes and additional signal alterations in deep gray matter or the genotype of codon 129.
conclusionThe distribution of cortical signal intensity abnormalities in patients with sCJD follows a common pattern, affecting mainly the cortical areas near the midline, the insula, cingulum, and the superior frontal cortex. DW imaging is superior to FLAIR in the detection of cortical high signal intensity.
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