Evidence map›Paper›PMID 17569867›Full record

ArticleScience (New York, N.Y.)2007

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

Roger A Hoskins, Joseph W Carlson, Cameron Kennedy, David Acevedo, Martha Evans-Holm, Erwin Frise, Kenneth H Wan, Soo Park, Maria Mendez-Lago, Fabrizio Rossi and 4 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed.

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  9. OligoY pipeline for full Y chromosome painting.Briefings in bioinformatics · 2025
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Roger A HoskinsDepartment of Genome and Computational Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Joseph W Carlson
Cameron Kennedy
David Acevedo
Martha Evans-Holm
Erwin Frise
Kenneth H Wan
Soo Park
Maria Mendez-Lago
Fabrizio Rossi
Alfredo Villasante
Patrizio Dimitri
Gary H Karpen
Susan E Celniker

Funding

TECHNICAL COREP50HG000750 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUBIN, GERALD M. · 1992 to 2002
$25.5M
The Drosophila Heterochromatin Genome ProjectR01HG000747 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 1992 to 2008
$9.3M
Determinants of Centromere Identity in DrosophilaR01GM066272 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2004 to 2011
$3.4M
NHGRI NIH HHS P50-HG00750NHGRI NIH HHS R01 HG000747NHGRI NIH HHS R01 HG00747NIGMS NIH HHS R01 GM066272
6 · The paper itself

Abstract

Genome sequences for most metazoans and plants are incomplete because of the presence of repeated DNA in the heterochromatin. The heterochromatic regions of Drosophila melanogaster contain 20 million bases (Mb) of sequence amenable to mapping, sequence assembly, and finishing. We describe the generation of 15 Mb of finished or improved heterochromatic sequence with the use of available clone resources and assembly methods. We also constructed a bacterial artificial chromosome-based physical map that spans 13 Mb of the pericentromeric heterochromatin and a cytogenetic map that positions 11 Mb in specific chromosomal locations. We have approached a complete assembly and mapping of the nonsatellite component of Drosophila heterochromatin. The strategy we describe is also applicable to generating substantially more information about heterochromatin in other species, including humans.

Indexed as

Sequence Analysis, DNAAnimalsChromosome MappingChromosomes, Artificial, BacterialContig MappingDrosophila melanogasterGenomeHeterochromatinIn Situ Hybridization, FluorescencePhysical Chromosome MappingHeterochromatin

Identifiers

PMID17569867
PMCPMC2825053

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.