ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2007
Understanding endothelial cell apoptosis: what can the transcriptome, glycome and proteome reveal?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
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- The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function.Science signaling · 2025Article
- Article
- Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics.bioRxiv : the preprint server for biology · 2023Article
- Trans-differentiation of trophoblast stem cells: implications in placental biology.Life science alliance · 2023Article
- SBIDDS Syndrome: A New Spoke of the Epigenetic Machinery Wheel.Molecular syndromology · 2023Article
- SARS-CoV-2 and Plasma Hypercoagulability.Cellular and molecular bioengineering · 2021Review
- Biphasic Effect of Pirfenidone on Angiogenesis.Frontiers in pharmacology · 2021Article
- Wnt3a promotes pro-angiogenic features in macrophages in vitro: Implications for stroke pathology.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury inOxidative medicine and cellular longevity · 2018Article
- The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass CarpBioMed research international · 2018Article
- HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium.Lipids in health and disease · 2017Article
- Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.Scientific reports · 2016Article
- CD31 signals confer immune privilege to the vascular endothelium.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Revisiting the pathogenesis of rheumatic fever and carditis.Nature reviews. Cardiology · 2013Review
- Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.BMC genomics · 2013Article
- Biological assessment of robust noise models in microarray data analysis.Bioinformatics (Oxford, England) · 2011Article
- Inference of gene regulatory networks using time-series data: a survey.Current genomics · 2009Article
- Introduction. Bioengineering the heart.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Endothelial cell (EC) apoptosis may play an important role in blood vessel development, homeostasis and remodelling. In support of this concept, EC apoptosis has been detected within remodelling vessels in vivo, and inactivation of EC apoptosis regulators has caused dramatic vascular phenotypes. EC apoptosis has also been associated with cardiovascular pathologies. Therefore, understanding the regulation of EC apoptosis, with the goal of intervening in this process, has become a current research focus. The protein-based signalling and cleavage cascades that regulate EC apoptosis are well known. However, the possibility that programmed transcriptome and glycome changes contribute to EC apoptosis has only recently been explored. Traditional bioinformatic techniques have allowed simultaneous study of thousands of molecular signals during the process of EC apoptosis. However, to progress further, we now need to understand the complex cause and effect relationships among these signals. In this article, we will first review current knowledge about the function and regulation of EC apoptosis including the roles of the proteome transcriptome and glycome. Then, we assess the potential for further bioinformatic analysis to advance our understanding of EC apoptosis, including the limitations of current technologies and the potential of emerging technologies such as gene regulatory networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.