ArticleWorld journal of gastroenterology2007
An overlap syndrome involving autoimmune hepatitis and systemic lupus erythematosus in childhood.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Cytopenias in Autoimmune Liver Diseases-A Review.Journal of clinical medicine · 2025Review
- Co-Presentation of Lupus Nephritis with Autoimmune Hepatitis.The American journal of case reports · 2023Article
- Gastrointestinal Involvement in Children with Systemic Lupus Erythematosus.Children (Basel, Switzerland) · 2023Review
- Co-occurrence of Wilson's disease and systemic lupus erythematosus: a case report and literature review.BMC gastroenterology · 2021Review
- Case of autoimmune hepatitis with overlap systemic lupus erythematosus.BMJ case reports · 2020Article
- Overlap Syndrome Involving Systemic Lupus Erythematosus and Autoimmune Hepatitis in Children: A Case Report and Literature Review.Frontiers in pediatrics · 2019Article
- [Research progress on systemic lupus erythematosus overlapping organ-specific autoimmune diseases].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review.Case reports in hematology · 2018Article
- Severe transaminitis in a paediatric patient with systemic lupus erythaematosus and a discussion of the literature.BMJ case reports · 2016Article
- Liver involvement in children with collagen vascular diseases.Clinical and experimental hepatology · 2015Review
- Association of autoimmune hepatitis and systemic lupus erythematodes: a case series and review of the literature.World journal of gastroenterology · 2014Review
- Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis.World journal of hepatology · 2014Review
- Features of systemic lupus erythematosus in patients with autoimmune hepatitis.Rheumatology international · 2013Article
- A patient of lupus presenting with myocarditis and overlapping autoimmune hepatitis.Case reports in rheumatology · 2011Article
- Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis.International journal of hepatology · 2011Article
- Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment.World journal of gastroenterology · 2009Review
- Liver in systemic disease.World journal of gastroenterology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a 12 years old female patient with an overlap syndrome involving autoimmune hepatitis (AIH) and systemic lupus erythematosus (SLE). The patient presented with jaundice, hepatosplenomegaly, malaise, polyarthralgia, arthritis and butterfly rash on the face. Laboratory tests revealed severe liver dysfunction, Coombs positive hemolytic anemia and a positive ANA/anti-dsDNA test. Renal biopsy showed class IIA kidney disease, while liver biopsy showed chronic hepatitis with severe inflammatory activity. The patient satisfied the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with high dose treatment with corticosteroids and azathioprine, however, remission of the liver disease could not be achieved. Repeat biopsy of the liver after three years of therapy revealed ongoing chronic hepatitis with high level of inflammatory activity. The present case indicates that children with liver dysfunction and SLE should be investigated for AIH. There is much diagnostic and therapeutic dilemma in patients with AIH-SLE overlap syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.