ArticleWorld journal of gastroenterology2007
Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Cytotoxic and Apoptotic Effects of Sultamicillin and Cefuroxime Axetil and Their Potential Transformation Products in RTG-2 Fish Gonad Cells.Cell biochemistry and biophysics · 2026Article
- Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.Experimental and therapeutic medicine · 2019Article
- Therapeutic Effects of Nano-HAp in a Rat Model of AlClIranian journal of pharmaceutical research : IJPR · 2019Article
- Analysis ofAdvances in pharmacological sciences · 2019Article
- Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil.Journal of pharmaceutical sciences · 2018Review
- Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite.Bioinorganic chemistry and applications · 2016Article
- Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review.Journal of functional biomaterials · 2015Review
- E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo.World journal of gastroenterology · 2015Article
- Integrative nanomedicine: treating cancer with nanoscale natural products.Global advances in health and medicine · 2014Review
- Amorphous calcium phosphate nanoparticles could function as a novel cancer therapeutic agent by employing a suitable targeted drug delivery platform.Nanoscale research letters · 2013Article
- Hydroxyapatite nanoparticles inhibit the growth of human glioma cells in vitro and in vivo.International journal of nanomedicine · 2012Article
- Development of a VX2 pancreatic cancer model in rabbits: a pilot study.Journal of vascular and interventional radiology : JVIR · 2009Article
- Influence of spray-dried hydroxyapatite-5-fluorouracil granules on cell lines derived from tissues of mesenchymal origin.Molecules (Basel, Switzerland) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effect of hydroxyapatite nano-particles (Nano HAP) by intravenous injection on the inhibition of implanted hepatic VX(2) tumor growth in rabbits and cell p53/c-Myc protein expression.
methods60 hepatic VX(2) tumor-bearing rabbits was randomly divided into five groups. Nano HAP collosol 20 mg/kg, 40 mg/kg, 5-FU solutions 20 mg/mL, mixed liquor of 5-FU solution 20 mg/mL and Nano HAP collosol 20 mg/kg were infused by vein, normal saline conducted as the control. The general state, weight, liver function and gross tumor volume were detected dynamically. The expression of p53 and c-Myc gene protein in tumor tissue was detected by immunohistochemistry methods.
resultsThe growth of implanted hepatic VX(2) tumors was significantly inhibited in all therapy groups, 3 wk after the injection, the tumor control rates in Nano HAP collosol groups were 25.5% and 32.5% respectively, and the gross tumor volumes were obviously less than that of control group. (24.81 +/- 5.17 and 22.73 +/- 4.23 vs 33.32 +/- 5.26, P<0.05). The tumor control rate of 5-FU group was 43.7% (18.74 +/- 4.40 vs 33.32 +/- 5.26, P<0.05), but the general state of the animals after injection aggravated; and the adverse reaction in the drug combination group obviously decreased. Due to the effect of Nano HAP, the positive expression of tumor associated the mutated p53 and c-Myc in tumor tissue was decreased obviously compared with the control group.
conclusionNano HAP has evident inhibitory action on rabbit implanted hepatic VX(2) tumor in vivo, which may be the result of decreasing the expression of the mutated p53 and c-myc, and drug combination can obviously decrease the adverse reaction of 5-FU.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.