ReviewWorld journal of gastroenterology2007
Survivin: potential role in diagnosis, prognosis and targeted therapy of gastric cancer.
Review in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Survivin -31G>C polymorphism and gastrointestinal tract cancer risk: a meta-analysis.PloS one · 2013Pooled it
- Immunohistochemical Expression of Survivin and Vascular Endothelial Growth Factor in Cervical Squamous Cell Carcinoma.Indian journal of surgical oncology · 2025Article
- Nanodiamonds and their potential applications in breast cancer therapy: a narrative review.Drug delivery and translational research · 2022Review
- Betanin Attenuates Oxidative Stress Induced by 6-OHDA in PC12 Cells via SAPK/JNK and PI3 K Pathways.Neurochemical research · 2020Article
- Application value of MRI diffuse weighted imaging combined with PET/CT in the diagnosis of stomach cancer at different stages.Oncology letters · 2019Article
- Is serum survivin expression a predictive biomarker in locally advanced gastric cancer patients treated with neoadjuvant chemotherapy?Cancer biomarkers : section A of Disease markers · 2018Article
- Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice.Current genomics · 2017Review
- Article
- Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma.Oncology letters · 2016Article
- Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients.Oncotarget · 2016Article
- Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression.Oncology letters · 2014Article
- Expression of serum survivin protein in diagnosis and prognosis of gallbladder cancer: a comparative study.Medical oncology (Northwood, London, England) · 2014Article
- Sandwich ELISA for detecting urinary Survivin in bladder cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Immunohistochemical expression of nuclear and cytoplasmic survivin in gastrointestinal carcinoma.International journal of clinical and experimental pathology · 2013Article
- Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population.Clinical and experimental medicine · 2011Article
- The role of survivin in diagnosis, prognosis and treatment of breast cancer.Journal of thoracic disease · 2010Article
- Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents.Cancer science · 2010Article
- Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival.Journal of translational medicine · 2009Article
- Clinical impact of aneuploidy on gastric cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7.International journal of nanomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survivin is a protein that is highly expressed in a vast number of malignancies, but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells, thus facilitating the growth of these cells. In the case of gastric cancer, survivin is over-expressed in tumor cells and plays a role in the carcinogenesis process. Several studies on gastric cancer have indicated that there is a relationship between survivin expression and the ultimate behavior of the carcinoma. Since the expression pattern of survivin is selective to cancer cells, it has been described as an "ideal target" for cancer therapy. Currently, several pre-clinical and clinical trials are on-going to investigate the effects of interfering with survivin function in cancer cells as a biologic therapy. Survivin is a potentially significant protein in the diagnosis, prognosis and treatment of gastric tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.