ArticleEuropean journal of applied physiology2007
Influence of the sample collection method on salivary interleukin-6 levels in resting and post-exercise conditions.
Article in European journal of applied physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The diagnostic value of salivary C-reactive protein in neonatal infections: a meta-analysis.Infection · 2024Pooled it
- The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- A Large Randomized Trial: Effects of Mindfulness-Based Stress Reduction (MBSR) for Breast Cancer (BC) Survivors on Salivary Cortisol and IL-6.Biological research for nursing · 2019Trial
- Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation.International journal of oral science · 2023Review
- Salivary Diagnostic for Monitoring Strenuous Exercise-A Pilot Study in a Cohort of Male Ultramarathon Runners.International journal of environmental research and public health · 2022Article
- The Effects of Exercise on Acute Immune Responses in Relative Leisure-Deprived People Living with HIV/AIDS: A Pilot Study.International journal of environmental research and public health · 2022Article
- Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.Psychoneuroendocrinology · 2021Review
- Best practice recommendations for the measurement and interpretation of salivary proinflammatory cytokines in biobehavioral research.Brain, behavior, and immunity · 2021Article
- C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African-Americans.Biomarkers in medicine · 2020Article
- The Effects of Whole-Body Photobiomodulation Light-Bed Therapy on Creatine Kinase and Salivary Interleukin-6 in a Sample of Trained Males: A Randomized, Crossover Study.Frontiers in sports and active living · 2020Article
- The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male.Scientific reports · 2018Article
- Posttraumatic Stress Disorder: An Immunological Disorder?Frontiers in psychiatry · 2017Review
- An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of Veterans with combat-related PTSD.Human immunology · 2016Article
- Potential Use of Salivary Markers for Longitudinal Monitoring of Inflammatory Immune Responses to Vaccination.Mediators of inflammation · 2016Review
- PTSD, a Disorder with an Immunological Component.Frontiers in immunology · 2016Review
- Salivary markers of inflammation in response to acute stress.Brain, behavior, and immunity · 2015Review
- Article
- The detection and measurement of interleukin-6 in venous and capillary blood samples, and in sweat collected at rest and during exercise.European journal of applied physiology · 2014Article
- Biomarkers of peripheral muscle fatigue during exercise.BMC musculoskeletal disorders · 2012Review
- Resting plasma and salivary IL-6 concentrations are not correlated in distance runners.European journal of applied physiology · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies demonstrated that no significant relationships exist between salivary and serum IL-6 in resting conditions and following exercise and that appropriate saliva collection procedures allow to avoid analytical drawbacks. This investigation aimed to: (a) compare the effects of two methods of saliva collection on IL-6 assay; (b) search for correlation between salivary and serum IL-6 in resting and post-exercise conditions; (c) evaluate the IL-6 response to isometric contractions. Seventeen sedentary subjects and fifteen athletes underwent one blood and two salivary draws: saliva was collected chewing on cotton salivettes and using a plastic straw (SA method and ST method, respectively). Afterwards, the athletes only completed a fatiguing isometric exercise of the knee extensors and blood and saliva were sampled after the exercise. In the entire group (n=32), ST method produced higher IL-6 levels than SA method and serum sampling. The exercise elicited significant responses of lactate, serum IL-6, salivary IL-6 (by ST method): salivary IL-6 values using the ST collection method were higher at each sampling point than with the SA method. The correlation analyses applied to both resting levels in the entire group and absolute changes above baseline in the athlete group showed that: (1) no significant relationships exist between serum and salivary IL-6 levels; (2) the greater the salivary IL-6 measurement, the higher the resultant inaccuracy of the SA method; (3) significant correlations exist between isometric force and mechanical fatigue during exercise and peaks of lactate and serum IL-6. These data provided demonstration of a cotton-interference effect for the results of salivary IL-6 assay and confirmed the lack of significant correlation between salivary and serum IL-6 in resting and post-exercise conditions.
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Registered trials
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