ArticleBiochemical and biophysical research communications2007
Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Ultrasound-mediated targeted micro/nanobubbles: breaking new boundaries in precision tumor therapy.International journal of surgery (London, England) · 2026Article
- Acoustofluidics-Based Intracellular Nanoparticle Delivery.Engineering (Beijing, China) · 2025Article
- The molecular impact of sonoporation: A transcriptomic analysis of gene regulation profile.Ultrasonics sonochemistry · 2024Article
- Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors.BME frontiers · 2022Review
- Translational research in pediatric contrast-enhanced ultrasound.Pediatric radiology · 2021Review
- Article
- Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells.Pharmaceutics · 2020Article
- Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds.Ultrasonics sonochemistry · 2020Article
- Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells.Pharmaceutics · 2020Article
- Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells.Pharmaceutics · 2019Article
- Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles.Ultrasound in medicine & biology · 2017Article
- Introduction of plasmids into gastric cancer cells by endoscopic ultrasound.Oncology letters · 2017Article
- Patient-Specific Therapy via Cell-Reprogramming Technology: a Curative Potential for Patients with Diabetes.Nanoscale research letters · 2015Article
- Article
- Sonoporation efficacy on SiHa cells in vitro at raised bath temperatures-experimental validation of a prototype sonoporation device.Journal of therapeutic ultrasound · 2015Article
- Effects of cell culture scaffold stiffness on cell membrane damage induced by sonoporation.Journal of medical ultrasonics (2001) · 2014Article
- Acoustic devices for particle and cell manipulation and sensing.Sensors (Basel, Switzerland) · 2014Article
- Ultrasound image-guided therapy enhances antitumor effect of cisplatin.Journal of medical ultrasonics (2001) · 2014Article
- Tertiary-amine functionalized polyplexes enhanced cellular uptake and prolonged gene expression.PloS one · 2014Article
- Sonoporation by low-frequency and low-power ultrasound enhances chemotherapeutic efficacy in prostate cancer cellsOncology letters · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ultrasound-induced intracellular drug delivery, sonoporation, is an appealing and promising technique for next generation drug delivery system. Many types of molecules, such as plasmid DNAs, siRNAs and peptides, have been demonstrated to be delivered into the cell by ultrasound with the aid of microbubbles both in vitro and in vivo. Although there are many reports on in vitro sonoporation, the efficiency of successful sonoporation and the viabilities of cells after the procedure documented in each report vary in a wide range, and the reasons for these differences are not fully understood. In this study, we have investigated how different experimental settings would affect sonoporation efficiency and cell viabilities after the procedure. Our results show that the fashion of cell culture (e.g. in suspension or in monolayer culture) and the presence of standing wave have a great impact on the overall results. These results indicate that in vitro sonoporation settings should be carefully evaluated in each experiment. The fact that standing wave is necessary to achieve high sonoporation efficiency may be a problematic issue for clinical application of sonoporation, as it may be difficult (although not impossible) to create standing wave in a human body.
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Registered trials
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