ArticleJournal of epidemiology and community health2007
Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer.
Article in Journal of epidemiology and community health, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies.Bioscience reports · 2016Pooled it
- The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study.BMC gastroenterology · 2025Article
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- Derivatives of Plastics as Potential Carcinogenic Factors: The Current State of Knowledge.Cancers · 2022Review
- Pancreatic Cancer (PDAC): Introduction of Evidence-Based Complementary Measures into Integrative Clinical Management.Cancers · 2020Review
- A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk.Nutrients · 2020Article
- Article
- Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.Journal of gastrointestinal cancer · 2013Article
- Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.European journal of epidemiology · 2011Article
- Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.International journal of cancer · 2010Article
- Clinical relevance of KRAS in human cancers.Journal of biomedicine & biotechnology · 2010Review
- Epidemiology of pancreatic cancer: an overview.Nature reviews. Gastroenterology & hepatology · 2009Review
- Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study.Cancer causes & control : CCC · 2009Article
- Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study.European journal of epidemiology · 2007Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo studies have investigated the relation between K-ras mutations and dietary factors in exocrine pancreatic cancer (EPC), and fewer than 10 studies have done so in other neoplasms. PATIENTS AND
methodsIncident cases of EPC were prospectively identified, and interviewed face-to-face during hospital admission. Food and nutrient intakes were measured with a food frequency questionnaire. Logistic regression was used to compare EPC cases (n = 107) with and without K-ras mutations (case-case study).
resultsK-ras mutations were more common among daily consumers of milk and other dairy products than among non-daily consumers: the odds ratio adjusted by total energy, age, sex, smoking, alcohol and coffee consumption (ORa) was 5.1 (95% CI 1.1 to 24.5, p = 0.040). For all dairy products, including butter, the ORa for the medium and upper tertiles of intake were 5.4 and 11.6, respectively (p for trend = 0.023). The ORa for regular coffee drinkers further adjusted by dairy consumption was 4.7 (95% CI 1.1 to 20.7, p = 0.043). K-ras mutated cases reported a lower intake of vitamin E (ORa = 0.2, p for trend = 0.036), polyunsaturated fats and omega 3 fatty acids (ORa = 0.2; p for trend <0.03).
conclusionsResults support the hypothesis that in EPC exposure to specific dietary components or contaminants may influence the occurrence or persistence of K-ras mutations.
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