ArticleGenome research2007
Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areas.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Review
- Article
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- H3K4 Methylation in Aging and Metabolism.Epigenomes · 2021Review
- Low Replicative Stress Triggers Cell-Type Specific Inheritable Advanced Replication Timing.International journal of molecular sciences · 2021Article
- Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.Cell reports · 2020Article
- Germline DNA replication timing shapes mammalian genome composition.Nucleic acids research · 2018Article
- Genomic Analysis of the DNA Replication Timing Program during Mitotic S Phase in Maize (The Plant cell · 2017Article
- The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion.PLoS genetics · 2016Article
- De novo identification of replication-timing domains in the human genome by deep learning.Bioinformatics (Oxford, England) · 2016Article
- Cell cycle control in the early embryonic development of aquatic animal species.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- Embryonic stem cell specific "master" replication origins at the heart of the loss of pluripotency.PLoS computational biology · 2015Article
- Complex correlations: replication timing and mutational landscapes during cancer and genome evolution.Current opinion in genetics & development · 2014Review
- A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells.PloS one · 2014Article
- The replication domain model: regulating replicon firing in the context of large-scale chromosome architecture.Journal of molecular biology · 2013Review
- Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins.Genome research · 2013Article
- DNA replication timing.Cold Spring Harbor perspectives in biology · 2013Review
- Alterations in replication timing of cancer-related genes in malignant human breast cancer cells.Journal of cellular biochemistry · 2013Article
- Sorting DNA with asymmetry: a new player in gene regulation?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- The spatiotemporal program of replication in the genome of Lachancea kluyveri.Genome biology and evolution · 2013Article
11 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
In eukaryotes, accurate control of replication time is required for the efficient completion of S phase and maintenance of genome stability. We present a high-resolution genome-tiling array-based profile of replication timing for approximately 1% of the human genome studied by The ENCODE Project Consortium. Twenty percent of the investigated segments replicate asynchronously (pan-S). These areas are rich in genes and CpG islands, features they share with early-replicating loci. Interphase FISH showed that pan-S replication is a consequence of interallelic variation in replication time and is not an artifact derived from a specific cell cycle synchronization method or from aneuploidy. The interallelic variation in replication time is likely due to interallelic variation in chromatin environment, because while the early- or late-replicating areas were exclusively enriched in activating or repressing histone modifications, respectively, the pan-S areas had both types of histone modification. The replication profile of the chromosomes identified contiguous chromosomal segments of hundreds of kilobases separated by smaller segments where the replication time underwent an acute transition. Close examination of one such segment demonstrated that the delay of replication time was accompanied by a decrease in level of gene expression and appearance of repressive chromatin marks, suggesting that the transition segments are boundary elements separating chromosomal domains with different chromatin environments.
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