ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Segmental, synaptic actions of commissural interneurons in the mouse spinal cord.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 130 citations in OpenAlex.
- Decreased spinal inhibition leads to undiversified locomotor patterns.Biological cybernetics · 2025Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.Current biology : CB · 2023Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.bioRxiv : the preprint server for biology · 2023Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- A model for self-organization of sensorimotor function: spinal interneuronal integration.Journal of neurophysiology · 2022Article
- Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling.International journal of molecular sciences · 2022Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Mapping the Dynamic Recruitment of Spinal Neurons during Fictive Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A dynamic role for dopamine receptors in the control of mammalian spinal networks.Scientific reports · 2020Article
- Rapid crossed responses in an intrinsic hand muscle during perturbed bimanual movements.Journal of neurophysiology · 2020Article
- The mammalian spinal commissural system: properties and functions.Journal of neurophysiology · 2020Review
- Crossed activation of thoracic trunk motoneurons by medullary reticulospinal neurons.Journal of neurophysiology · 2019Article
- Walking and finger tapping can be done with independent rhythms.Scientific reports · 2019Article
- Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord.Frontiers in cellular neuroscience · 2019Review
- Spinal V3 Interneurons and Left-Right Coordination in Mammalian Locomotion.Frontiers in cellular neuroscience · 2019Article
- Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Expressions of VGLUT1/2 in the inspiratory interneurons and GAD65/67 in the inspiratory Renshaw cells in the neonatal rat upper thoracic spinal cord.IBRO reports · 2018Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Left-right alternation depends on activity in commissural interneurons (CINs) that have axons crossing in the midline. In this study, we investigate the CIN connectivity to local motor neurons using a newly developed preparation of the in vitro neonatal mouse spinal cord that allows us to identify all classes of CINs. Nineteen of 29 short-range CINs with axonal projections <1.5 segments (sCINs) directly excited, directly inhibited, or indirectly inhibited contralateral motor neurons in the quiescent spinal cord. Excitation was glutamatergic and inhibition was mixed glycinergic and/or GABAergic. Long-range CINs were also found to have input to local, contralateral motor neurons. Thirteen of 29 descending CINs had similar synaptic connectivity to contralateral motor neurons as the sCINs, including direct excitation and direct and indirect inhibition. Some (9 of 23) rostrally projecting ascending CINs, and a few (2 of 10) CINs with bifurcating axons that both ascend and descend, indirectly inhibited local, contralateral motor neurons. Rhythmic firing during locomotor-like activity was observed in a number of CINs with segmental synaptic effects on contralateral motor neurons. This study outlines the basic connectivity pattern of CINs in the mouse spinal cord on a segmental level. Our study suggests that, based on observed synaptic connectivity, both short- and long-range CINs are likely involved in segmental left-right coordination and that the CIN system is organized into a dual-inhibitory and single-excitatory system. These systems are organized in a way that they could provide appropriate coordination during locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.