ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Adaptation reduces spike-count reliability, but not spike-timing precision, of auditory nerve responses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Neural adaptation and behavioral measures of temporal processing and speech perception in cochlear implant recipients.PloS one · 2013Trial
- Single Neuron Contributions to the Auditory Brainstem EEG.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Adaptation in auditory processing.Physiological reviews · 2023Review
- Neural synchrony in cortical networks: mechanisms and implications for neural information processing and coding.Frontiers in integrative neuroscience · 2022Article
- Phase-Locking Requires Efficient CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Foreground stimuli and task engagement enhance neuronal adaptation to background noise in the inferior colliculus of macaques.Journal of neurophysiology · 2020Article
- The Impact of Frequency Scale on the Response Sensitivity and Reliability of Cortical Neurons to 1/fFrontiers in cellular neuroscience · 2019Article
- Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapse.Neuron · 2014Article
- The meaning of spikes from the neuron's point of view: predictive homeostasis generates the appearance of randomness.Frontiers in computational neuroscience · 2014Article
- Why do forward maskers affect auditory intensity discrimination? Evidence from "molecular psychophysics".PloS one · 2014Article
- Predicting spike timing in highly synchronous auditory neurons at different sound levels.Journal of neurophysiology · 2013Article
- Proportional spike-timing precision and firing reliability underlie efficient temporal processing of periodicity and envelope shape cues.Journal of neurophysiology · 2013Article
- Refractoriness enhances temporal coding by auditory nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuronal precision and the limits for acoustic signal recognition in a small neuronal network.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Modulation of temporal precision in thalamic population responses to natural visual stimuli.Frontiers in systems neuroscience · 2010Article
- The origin of adaptation in the auditory pathway of locusts is specific to cell type and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Timing precision in population coding of natural scenes in the early visual system.PLoS biology · 2008Article
- Adaptation of firing rate and spike-timing precision in the avian cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Synaptic ribbon enables temporal precision of hair cell afferent synapse by increasing the number of readily releasable vesicles: a modeling study.Journal of neurophysiology · 2008Article
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4 authors.
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Abstract
Sensory systems use adaptive coding mechanisms to filter redundant information from the environment to efficiently represent the external world. One such mechanism found in most sensory neurons is rate adaptation, defined as a reduction in firing rate in response to a constant stimulus. In auditory nerve, this form of adaptation is likely mediated by exhaustion of release-ready synaptic vesicles in the cochlear hair cell. To better understand how specific synaptic mechanisms limit neural coding strategies, we examined the trial-to-trial variability of auditory nerve responses during short-term rate-adaptation by measuring spike-timing precision and spike-count reliability. After adaptation, precision remained unchanged, whereas for all but the lowest-frequency fibers, reliability decreased. Modeling statistical properties of the hair cell-afferent fiber synapse suggested that the ability of one or a few vesicles to elicit an action potential reduces the inherent response variability expected from quantal neurotransmitter release, and thereby confers the observed count reliability at sound onset. However, with adaptation, depletion of the readily releasable pool of vesicles diminishes quantal content and antagonizes the postsynaptic enhancement of reliability. These findings imply that during the course of short-term adaptation, coding strategies that employ a rate code are constrained by increased neural noise because of vesicle depletion, whereas those that employ a temporal code are not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.