ArticleThe EMBO journal1991
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Tfh Cells in Health and Immunity: Potential Targets for Systems Biology Approaches to Vaccination.International journal of molecular sciences · 2020Review
- Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.Immunological reviews · 2019Review
- Cellular choreography in the germinal center: new visions from in vivo imaging.Seminars in immunopathology · 2010Review
- Molecular mechanism and function of CD40/CD40L engagement in the immune system.Immunological reviews · 2009Review
- Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.The Journal of experimental medicine · 1998Article
- Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.The Journal of experimental medicine · 1998Article
- Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.The EMBO journal · 1997Article
- An immunoglobulin mutator that targets G.C base pairs.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.The Journal of experimental medicine · 1995Article
- Analysis of somatic mutation in five B cell subsets of human tonsil.The Journal of experimental medicine · 1994Article
- Comparison of somatic mutation frequency among immunoglobulin genes.The Journal of experimental medicine · 1994Article
- Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.The Journal of experimental medicine · 1993Article
- Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.The Journal of experimental medicine · 1993Article
- Somatic hypermutation of an immunoglobulin mu heavy chain transgene.The Journal of experimental medicine · 1993Article
- Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.The Journal of experimental medicine · 1992Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously demonstrated that B lymphocyte specific somatic mutations are introduced into the variable regions of immunoglobulin kappa transgenes in two independent transgenic mouse lines. The frequency, distribution and nature of these mutations strongly suggest that they arose as a result of the process of somatic hypermutation, which is responsible, in part, for affinity maturation during an immune response. Unexpectedly, in these multiple copy transgenic lines, many of the transgene copies showed no evidence of somatic mutation. This paradox was addressed by determining the sequence of each transgene copy in several B cell hybridomas derived from a mouse line carrying three copies of the kappa transgene. It was found that the somatic hypermutation process in different B cells from the same mouse preferentially targets one, but not the same, transgene copy. We present a model, based on the pattern of this targeting, which links somatic hypermutation to the orientation of the Ig gene relative to the direction of DNA replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.