ArticleNeuroImage2007
Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome.
Article in NeuroImage, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Quality Assurance Strategies for Brain State Characterization by MEMRI.bioRxiv : the preprint server for biology · 2026Article
- Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025Article
- Application of fluorescence micro-optical sectioning tomography in the cerebrovasculature and applicable vascular labeling methods.Brain structure & function · 2023Review
- Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains.Frontiers in cell and developmental biology · 2023Article
- Longitudinal manganese-enhanced magnetic resonance imaging of neural projections and activity.NMR in biomedicine · 2022Review
- Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI).Methods in molecular biology (Clifton, N.J.) · 2022Article
- Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI.NeuroImage · 2020Article
- Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain.Frontiers in cellular neuroscience · 2019Article
- Alterations of functional circuitry in aging brain and the impact of mutated APP expression.Neurobiology of aging · 2018Article
- In Vivo Evaluation of Neuronal Transport in Murine Models of Neurodegeneration Using Manganese-Enhanced MRI.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Automated Computational Processing of 3-D MR Images of Mouse Brain for Phenotyping of Living Animals.Current protocols in molecular biology · 2017Article
- Hippocampal to basal forebrain transport of MnNeuroImage · 2017Article
- A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head.Journal of neuroscience methods · 2016Article
- Fluorescence micro-optical sectioning tomography using acousto-optical deflector-based confocal scheme.Neurophotonics · 2015Article
- Article
- Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI.NeuroImage · 2013Article
- Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.NeuroImage · 2012Article
- From axonal transport to mitochondrial trafficking: What can we learn from Manganese-Enhanced MRI studies in mouse models of Alzheimers disease?Current medical imaging reviews · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Connections from hippocampus to septal nuclei have been implicated in memory loss and the cognitive impairment in Down syndrome (DS). We trace these connections in living mice by Mn(2+) enhanced 3D MRI and compare normal with a trisomic mouse model of DS, Ts65Dn. After injection of 4 nl of 200 mM Mn(2+) into the right hippocampus, Mn(2+) enhanced circuitry was imaged at 0.5, 6, and 24 h in each of 13 different mice by high resolution MRI to detect dynamic changes in signal over time. The pattern of Mn(2+) enhanced signal in vivo correlated with the histologic pattern in fixed brains of co-injected 3kD rhodamine-dextran-amine, a classic tracer. Statistical parametric mapping comparing intensity changes between different time points revealed that the dynamics of Mn(2+) transport in this pathway were surprisingly more robust in DS mice than in littermate controls, with statistically significant intensity changes in DS appearing at earlier time points along expected pathways. This supports reciprocal alterations of transport in the hippocampal-forebrain circuit as being implicated in DS and argues against a general failure of transport. This is the first examination of in vivo transport dynamics in this pathway and the first report of elevated transport in DS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.