ReviewSociety of Reproduction and Fertility supplement2007
Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha.
Review in Society of Reproduction and Fertility supplement, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Development of a Second-Generation RARα Selective Antagonist as an Orally Bioavailable, Effective, Safe, and Reversible Male Contraceptive.Journal of medicinal chemistry · 2026Article
- Development of the retinoic acid receptor alpha-specific antagonist YCT-529 for male contraception: A brief review.Contraception · 2025Review
- Retinoic acid receptor antagonists for male contraception: current status†.Biology of reproduction · 2020Review
- Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function.Development (Cambridge, England) · 2018Article
- Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu.Frontiers in genetics · 2017Article
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes.Development (Cambridge, England) · 2016Article
- Article
- Spermatogenesis: The Commitment to Meiosis.Physiological reviews · 2016Review
- Long-term vitamin A deficiency induces alteration of adult mouse spermatogenesis and spermatogonial differentiation: direct effect on spermatogonial gene expression and indirect effects via somatic cells.The Journal of nutritional biochemistry · 2013Article
- Pharmacological activity of retinoic acid receptor alpha-selective antagonistsACS medicinal chemistry letters · 2013Article
- Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.Nucleic acids research · 2012Article
- Retinyl ester hydrolases and their roles in vitamin A homeostasis.Biochimica et biophysica acta · 2012Review
- Oral administration of a retinoic Acid receptor antagonist reversibly inhibits spermatogenesis in mice.Endocrinology · 2011Article
- A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid.The Journal of biological chemistry · 2010Article
- Aberrant distribution of junctional complex components in retinoic acid receptor alpha-deficient mice.Microscopy research and technique · 2010Article
- Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis.Development (Cambridge, England) · 2009Article
- Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone.Molecular reproduction and development · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The importance of dietary retinol (vitamin A) and retinoid signaling for normal development and differentiation has been recognised for many years. Vitamin A deficiency results in a variety of abnormalities, most of which can be corrected by supplementing the diet with all-trans-retinoic acid (ATRA), with the exception of blindness and male sterility. ATRA, an active metabolite of vitamin A, functions primarily by binding to nuclear receptors of the steroid hormone superfamily, the retinoic acid receptors (RARs). Gene targeting studies revealed the importance of ATRA signaling through the RARs for spermatogenesis. Mice that are homozygous for a null mutation in the gene encoding RARalpha, Rara-/-, exhibit defects in spermatogenesis and male sterility. The abnormalities in these RARalpha-deficient testes have been examined in detail in a series of recent studies from our laboratory and will be summarised in this paper. We also review how dietary, pharmacologic and genetic strategies, alone or in combination, can be used to gain further insight into retinoid function in mammalian spermatogenesis.
Indexed as
Identifiers
17566257PMC3796155W1535905403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.