ArticleGenetics2007
Estimation of multilocus linkage disequilibria in diploid populations with dominant markers.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Potential of Genomic Selection in Mass Selection Breeding of an Allogamous Crop: An Empirical Study to Increase Yield of Common Buckwheat.Frontiers in plant science · 2018Article
- Genetic diversity, linkage disequilibrium, and association mapping analyses of Gossypium barbadense L. germplasm.PloS one · 2017Article
- Constructing a linkage-linkage disequilibrium map using dominant-segregating markers.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Development of SSR Markers in Hickory (Carya cathayensis Sarg.) and Their Transferability to Other Species of Carya.Current genomics · 2014Article
- Will genomic selection be a practical method for plant breeding?Annals of botany · 2012Review
- A genome scan and linkage disequilibrium analysis among chromosomal races of the Australian grasshopper Vandiemenella viatica.PloS one · 2012Article
- Model and algorithm for linkage disequilibrium analysis in a non-equilibrium population.Frontiers in genetics · 2012Article
- A first insight into population structure and linkage disequilibrium in the US peanut minicore collection.Genetica · 2011Article
- Linkage disequilibrium based association mapping of fiber quality traits in G. hirsutum L. variety germplasm.Genetica · 2009Article
- Application of association mapping to understanding the genetic diversity of plant germplasm resources.International journal of plant genomics · 2008Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Analysis of population structure and organization with DNA-based markers can provide important information regarding the history and evolution of a species. Linkage disequilibrium (LD) analysis based on allelic associations between different loci is emerging as a viable tool to unravel the genetic basis of population differentiation. In this article, we derive the EM algorithm to obtain the maximum-likelihood estimates of the linkage disequilibria between dominant markers, to study the patterns of genetic diversity for a diploid species. The algorithm was expanded to estimate and test linkage disequilibria of different orders among three dominant markers and can be technically extended to manipulate an arbitrary number of dominant markers. The feasibility of the proposed algorithm is validated by an example of population genetic studies of hickory trees, native to southeastern China, using dominant random amplified polymorphic DNA markers. Extensive simulation studies were performed to investigate the statistical properties of this algorithm. The precision of the estimates of linkage disequilibrium between dominant markers was compared with that between codominant markers. Results from simulation studies suggest that three-locus LD analysis displays increased power of LD detection relative to two-locus LD analysis. This algorithm is useful for studying the pattern and amount of genetic variation within and among populations.
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