ArticleGenetics2007
Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Conservation status and historical relatedness of South African communal indigenous goat populations using a genome-wide single-nucleotide polymorphism marker.Frontiers in genetics · 2022Article
- Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil.Frontiers in genetics · 2021Article
- Mapping genomic regions affecting milk traits in Sarda sheep by using the OvineSNP50 Beadchip and principal components to perform combined linkage and linkage disequilibrium analysis.Genetics, selection, evolution : GSE · 2019Article
- Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation.Genetics, selection, evolution : GSE · 2018Article
- Current advances in chickpea genomics: applications and future perspectives.Plant cell reports · 2018Review
- Contributions of linkage disequilibrium and co-segregation information to the accuracy of genomic prediction.Genetics, selection, evolution : GSE · 2016Article
- Meuwissen et al. on Genomic Selection.Genetics · 2016Article
- Confirmation of a non-synonymous SNP in PNPLA8 as a candidate causal mutation for Weaver syndrome in Brown Swiss cattle.Genetics, selection, evolution : GSE · 2016Article
- A crossbred reference population can improve the response to genomic selection for crossbred performance.Genetics, selection, evolution : GSE · 2015Article
- Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Genetics, selection, evolution : GSE · 2014Article
- Bayesian model selection for multiple QTLs mapping combining linkage disequilibrium and linkage.Genetics research · 2014Article
- Inferring demography from runs of homozygosity in whole-genome sequence, with correction for sequence errors.Molecular biology and evolution · 2013Article
- A fast expectation-maximum algorithm for fine-scale QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Optimum contribution selection for conserved populations with historic migration.Genetics, selection, evolution : GSE · 2012Article
- Joint analysis of quantitative trait loci and major-effect causative mutations affecting meat quality and carcass composition traits in pigs.BMC genetics · 2011Article
- Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids.BMC genomics · 2011Article
- Review
- Reconciling the analysis of IBD and IBS in complex trait studies.Nature reviews. Genetics · 2010Review
- Article
- Combined detection and introgression of QTL in outbred populations.Genetics, selection, evolution : GSE · 2010Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel multipoint method, based on an approximate coalescence approach, to analyze multiple linked markers is presented. Unlike other approximate coalescence methods, it considers all markers simultaneously but only two haplotypes at a time. We demonstrate the use of this method for linkage disequilibrium (LD) mapping of QTL and estimation of effective population size. The method estimates identity-by-descent (IBD) probabilities between pairs of marker haplotypes. Both LD and combined linkage and LD mapping rely on such IBD probabilities. The method is approximate in that it considers only the information on a pair of haplotypes, whereas a full modeling of the coalescence process would simultaneously consider all haplotypes. However, full coalescence modeling is computationally feasible only for few linked markers. Using simulations of the coalescence process, the method is shown to give almost unbiased estimates of the effective population size. Compared to direct marker and haplotype association analyses, IBD-based QTL mapping showed clearly a higher power to detect a QTL and a more realistic confidence interval for its position. The modeling of LD could be extended to estimate other LD-related parameters such as recombination rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.