ArticleGenetics2007
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles ineLife · 2024Article
- Drivers of linkage disequilibrium across a species' geographic range.PLoS genetics · 2021Article
- Evolution of self-incompatibility in the Brassicaceae: Lessons from a textbook example of natural selection.Evolutionary applications · 2020Article
- Targeted Long-Read Sequencing of a Locus Under Long-Term Balancing Selection inG3 (Bethesda, Md.) · 2018Article
- Article
- Article
- Article
- Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species.Evolution; international journal of organic evolution · 2015Article
- Article
- Recent and ancient signature of balancing selection around the S-locus in Arabidopsis halleri and A. lyrata.Molecular biology and evolution · 2013Article
- Inbreeding depression in self-incompatible North-American Arabidopsis lyrata: disentangling genomic and S-locus-specific genetic load.Heredity · 2013Article
- Review
- Contrasted patterns of molecular evolution in dominant and recessive self-incompatibility haplotypes in Arabidopsis.PLoS genetics · 2012Article
- Evolution of the S-locus region in Arabidopsis relatives.Plant physiology · 2011Article
- Creation and maintenance of variation in allorecognition Loci: molecular analysis in various model systems.Frontiers in immunology · 2011Article
- Arabidopsis and relatives as models for the study of genetic and genomic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Article
- Evolutionary strata in a small mating-type-specific region of the smut fungus Microbotryum violaceum.Genetics · 2009Article
- Antagonism between local dispersal and self-incompatibility systems in a continuous plant population.Molecular ecology · 2009Article
- Recent speciation of Capsella rubella from Capsella grandiflora, associated with loss of self-incompatibility and an extreme bottleneck.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity is unusually high at loci in the S-locus region of the self-incompatible species of the flowering plant, Arabidopsis lyrata, not just in the S loci themselves, but also at two nearby loci. In a previous study of a single natural population from Iceland, we attributed this elevated polymorphism to linkage disequilibrium (LD) between variants at loci close to the S locus and the S alleles, which are maintained in the population by balancing selection. With the four S-flanking loci whose diversity we previously studied, we could not determine the extent of the region linked to the S loci in which neutral sites are affected. We also could not exclude the possibility of a population bottleneck, or of admixture, as causes of the LD. We have now studied four more distant loci flanking the S-locus region, and more populations, and we analyze the results using a theoretical model of the effect of balancing selection on diversity at linked neutral sites within and between different functional S-allelic classes. In the model, diversity is a function of the number of selectively maintained alleles and the recombination distances from the selectively maintained sites. We use the model to estimate the number of different functional S alleles, their turnover rate, and recombination rates between the S-locus region and other loci. Our estimates suggest that there is a small region of very low recombination surrounding the S-locus region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.