ArticleGenetics2007
Predicting the size of the progeny mapping population required to positionally clone a gene.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Understanding grain development in the Poaceae family by comparing conserved and distinctive pathways through omics studies in wheat and maize.Frontiers in plant science · 2024Review
- Genome-wide association study presents insights into the genetic architecture of drought tolerance in maize seedlings under field water-deficit conditions.Frontiers in plant science · 2023Article
- Functional Allele Validation by Gene Editing to Leverage the Wealth of Genetic Resources for Crop Improvement.International journal of molecular sciences · 2022Review
- Genome-wide association studies for soybean epicotyl length in two environments using 3VmrMLM.Frontiers in plant science · 2022Article
- Recent Advances for Drought Stress Tolerance in Maize (Frontiers in plant science · 2022Review
- Combined QTL mapping and association study reveals candidate genes for leaf number and flowering time in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genetic dissection of maize drought tolerance for trait improvement.Molecular breeding : new strategies in plant improvement · 2021Review
- A novel, validated, and plant height-independent QTL for spike extension length is associated with yield-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Fine mapping and gene cloning in the post-NGS era: advances and prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- QTG-Finder: A Machine-Learning Based Algorithm To Prioritize Causal Genes of Quantitative Trait Loci in Arabidopsis and Rice.G3 (Bethesda, Md.) · 2019Article
- High Resolution Genetic and Physical Mapping of a Major Powdery Mildew Resistance Locus in Barley.Frontiers in plant science · 2019Article
- Development of a next-generation NIL library in Arabidopsis thaliana for dissecting complex traits.BMC genomics · 2013Article
- Genetic analysis of root elongation induced by phosphorus deficiency in rice (Oryza sativa L.): fine QTL mapping and multivariate analysis of related traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key frustration during positional gene cloning (map-based cloning) is that the size of the progeny mapping population is difficult to predict, because the meiotic recombination frequency varies along chromosomes. We describe a detailed methodology to improve this prediction using rice (Oryza sativa L.) as a model system. We derived and/or validated, then fine-tuned, equations that estimate the mapping population size by comparing these theoretical estimates to 41 successful positional cloning attempts. We then used each validated equation to test whether neighborhood meiotic recombination frequencies extracted from a reference RFLP map can help researchers predict the mapping population size. We developed a meiotic recombination frequency map (MRFM) for approximately 1400 marker intervals in rice and anchored each published allele onto an interval on this map. We show that neighborhood recombination frequencies (R-map, >280-kb segments) extracted from the MRFM, in conjunction with the validated formulas, better predicted the mapping population size than the genome-wide average recombination frequency (R-avg), with improved results whether the recombination frequency was calculated as genes/cM or kb/cM. Our results offer a detailed road map for better predicting mapping population size in diverse eukaryotes, but useful predictions will require robust recombination frequency maps based on sampling more progeny.
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