ArticleBMC medical genetics2007
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis.
Article in BMC medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association of the CCR5 gene with juvenile idiopathic arthritis.Genes and immunity · 2010Pooled it
- The Role of MECP2 and CCR5 Polymorphisms on the Development and Course of Systemic Lupus Erythematosus.Biomolecules · 2020Trial
- New discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis.Expert review of clinical immunology · 2024Review
- Metabolomics as an Approach to Characterise the Contrasting Roles of CCR5 in the Presence and Absence of Disease.International journal of molecular sciences · 2020Review
- The HIV co-receptor CCR5 regulates osteoclast function.Nature communications · 2017Article
- Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- Association analysis of the CCL3L1 copy number locus by paralogue ratio test in Norwegian rheumatoid arthritis patients and healthy controls.Genes and immunity · 2012Article
- Considerations About the Role of the CCR5 Gene in Juvenile Idiopathic Arthritis - Look at the Whole or Put All Parts Together?The open rheumatology journal · 2011Article
- A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.PloS one · 2011Article
- Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.Arthritis research & therapy · 2010Article
- Chemokines and chemokine receptors in arthritis.Frontiers in bioscience (Scholar edition) · 2010Review
- Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.Genes and immunity · 2010Article
- Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis.Arthritis research & therapy · 2009Article
- A comprehensive review of the genetics of juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2008Article
- [Concepts on the pathogenesis of juvenile idiopathic arthritis].Zeitschrift fur Rheumatologie · 2008Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe chemokine receptor CCR5 has been detected at elevated levels on synovial T cells, and a 32 bp deletion in the CCR5 gene leads to a non-functional receptor. A negative association between the CCR5Delta32 and rheumatoid arthritis (RA) has been reported, although with conflicting results. In juvenile idiopathic arthritis (JIA), an association with CCR5 was recently reported. The purpose of this study was to investigate if the CCR5Delta32 polymorphism is associated with RA or JIA in Norwegian cohorts.
methods853 RA patients, 524 JIA patients and 658 controls were genotyped for the CCR5Delta32 polymorphism.
resultsThe CCR5Delta32 allele frequency was 11.5% in the controls vs. 10.4% in RA patients (OR = 0.90; P = 0.36) and 9.7% in JIA patients (OR = 0.85; P = 0.20). No decreased homozygosity was observed for CCR5Delta32, as previously suggested.
conclusionOur data do not support an association between the CCR5Delta32 allele and Norwegian RA or JIA patients. Combining our results with those from a recently published meta-analysis still provide evidence for a role for CCR5Delta32 in RA, albeit substantially weaker than the effect first reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.