ArticleDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2007
[Simultaneous pancreas-kidney transplantation. Influence of donor and recipient gender].
Article in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Influence of donor and recipient sex on outcomes following simultaneous pancreas-kidney transplantation in the new millennium: Single-center experience and review of the literature.Clinical transplantation · 2023Review
- Sex matching does not impact the outcome after simultaneous pancreas-kidney transplantation.Clinical transplantation · 2019Article
- Gender Mainstreaming and Transplant Surgery.Visceral medicine · 2016Review
- Influence of donor-recipient sex mismatch on long-term survival of pancreatic grafts.Scientific reports · 2016Article
- Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation.Langenbeck's archives of surgery · 2010Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferences in graft survival due to gender have been reported after transplantation of the kidney, liver, and heart. However, little is known about the role of donor and recipient gender in simultaneous pancreas-kidney transplantation.
methodsSingle-centre analysis was performed of first simultaneous pancreas-kidney transplantations performed between 1994 and 2005 at the Bochum Transplant Center in Germany (n=218).
resultsRecipients of female donor organs exhibited acute organ rejections earlier and more frequently (P<0.05). Male recipients of organs from male donors had a lower risk of acute rejection than recipients of female donor organs (P<0.05). In addition to female donor gender, higher donor age and early kidney dysfunction were risk factors for perioperative rejection (P<0.05). Long-term kidney and pancreas function was best in male-donor-to-female-recipient transplants over the time periods of 7 and 3 years, respectively (P<0.05). Risk factors of long-term organ failure were: the need of revision laparotomy, organ rejection, and early postoperative organ dysfunction (P<0.05).
conclusionThis is the first report of graft function after simultaneous pancreas-kidney transplantation looking specifically at gender differences with respect to donor and recipient. There was an increased risk of organ rejection of female donor organs.
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