ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Defining the expression pattern of the LGI1 gene in BAC transgenic mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Clinical Characteristics and Outcomes of Early-Onset Versus Late-Onset LGI1-Antibody Encephalitis.Annals of clinical and translational neurology · 2026Article
- Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models.Brain, behavior, and immunity · 2025Article
- Clinical, Electroencephalogram and Imaging Characteristics of Patients With Anti-LGI1 Antibody Encephalitis: A Multicenter Cohort Study.CNS neuroscience & therapeutics · 2025Article
- Origin and significance of leucine-rich glioma-inactivated 1 antibodies in cerebrospinal fluid.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head.Neurology(R) neuroimmunology & neuroinflammation · 2023Review
- Comparison of quantitative FDG-PET and MRI in anti-LGI1 autoimmune encephalitis.Neuroradiology · 2023Article
- Leucine-rich Glioma-inactivated 1 Encephalitis Followed by Isaacs Syndrome: Alternating Presence of Pathogenic Autoantibodies to Leucine-rich Glioma-inactivated 1 and Contactin-associated Protein-like 2.Internal medicine (Tokyo, Japan) · 2023Article
- The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Cellular and molecular life sciences : CMLS · 2021Review
- Assembly of Multiple Full-Size Genes or Genomic DNA Fragments on Human Artificial Chromosomes Using the Iterative Integration System.Current protocols · 2021Article
- Clinical Characteristics and Long-Term Prognosis of Anti-LGI1 Encephalitis: A Single-Center Cohort Study in Beijing, China.Frontiers in neurology · 2021Article
- Psychiatric Manifestation of Anti-LGI1 Encephalitis.Brain sciences · 2020Article
- Coexistence of Autoimmune Encephalitis and Other Systemic Autoimmune Diseases.Frontiers in neurology · 2019Article
- Possible anti-VGKC autoimmune limbic encephalitis associated with SIADH.BMJ case reports · 2018Article
- Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling.Frontiers in molecular neuroscience · 2018Article
- Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders.Nature reviews. Neuroscience · 2017Review
- Homozygous Deletion of the LGI1 Gene in Mice Leads to Developmental Abnormalities Resulting in Cortical Dysplasia.Brain pathology (Zurich, Switzerland) · 2015Article
- Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum.Scientific reports · 2015Article
- Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures.Brain : a journal of neurology · 2014Article
- Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.Neuroscience · 2013Review
- LGI proteins in the nervous system.ASN neuro · 2013Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The LGI1 gene has been implicated in the development of epilepsy and the invasion phenotype of glial cells. Controversy over the specific tissue expression pattern of this gene has stemmed from conflicting reports generated using immunohistochemistry and the polymerase chain reaction. LGI1 is one of a four-member family of secreted proteins with high homology and here we demonstrate, using GFP-tagged constructs from the four LGI1family members, that commonly used antibodies against LGI1 cross-react with different family members. With the uncertainty surrounding the use of commercially available antibodies to truly establish the expression pattern of LGI1, we generated transgenic mice carrying the LGI1-containing BAC, RP23-127G7, which had been modified to express the GFP reporter gene under the control of the endogenous regulatory elements required for LGI1 expression. Three founder mice were generated, and immunohistochemistry was used to determine the tissue-specific pattern of expression. In the brain, distinct regions of glial and neuronal cell expression were identified, as well as the choriod plexus, which is largely pia-derived. In addition, strong expression levels were identified in glandular regions of the prostate, individual tubules in the kidney, sympathetic ganglia in the kidney, sebaceous glands in the skin, the islets of Langerhans, the endometrium, and the ovary and testes. All other major organs analyzed were negative. The pattern of reporter gene expression was identical in three individual founder mice, arguing against a position effect altering expression profile due to the integration site of the BAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.