ArticlePloS one2007
Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.Translational psychiatry · 2024Article
- Article
- p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.Cells · 2021Article
- Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.Cell stem cell · 2018Article
- Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90.PloS one · 2017Article
- The NuRD complex component p66 suppresses photoreceptor neuron regeneration in planarians.Regeneration (Oxford, England) · 2016Article
- Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Genes & development · 2014Article
- Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.Immunological reviews · 2014Review
- A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.Journal of proteome research · 2013Article
- CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now.Biochemical Society transactions · 2013Review
- Chromatin-remodeling complex specificity and embryonic vascular development.Cellular and molecular life sciences : CMLS · 2012Review
- Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.Epigenomics · 2012Review
- Chromatin remodeling system, cancer stem-like attractors, and cellular reprogramming.Cellular and molecular life sciences : CMLS · 2011Article
- Physiological roles of class I HDAC complex and histone demethylase.Journal of biomedicine & biotechnology · 2011Review
- Open chromatin in pluripotency and reprogramming.Nature reviews. Molecular cell biology · 2011Review
- Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development.The international journal of biochemistry & cell biology · 2009Review
- Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.Nature reviews. Molecular cell biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe NuRD/Mi2 chromatin complex is involved in histone modifications and contains a large number of subunits, including the p66 protein. There are two mouse and human p66 paralogs, p66alpha and p66beta. The functions of these genes are not clear, in part because there are no mutants available, except in invertebrate model systems. METHODOLOGY: We made loss of function mutants in the mouse p66alpha gene (mp66alpha, official name Gatad2a, MGI:2384585). We found that mp66alpha is essential for development, as mutant embryos die around day 10 of embryogenesis. The gene is not required for normal blastocyst development or for implantation. The phenotype of mutant embryos and the pattern of gene expression in mutants are consistent with a role of mp66alpha in gene silencing.
conclusionmp66alpha is an essential gene, required for early mouse development. The lethal phenotype supports a role in execution of methylated DNA silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.