ReviewCurrent opinion in nephrology and hypertension2007
Mineral metabolism and aging: the fibroblast growth factor 23 enigma.
Review in Current opinion in nephrology and hypertension, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The Changes of Blood and CSF Ion Levels in Depressed Patients: a Systematic Review and Meta-analysis.Molecular neurobiology · 2024Pooled it
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- The association of fibroblast growth factor 23 at mid-life and late-life with subsequent risk of cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) Study.American heart journal plus : cardiology research and practice · 2022Article
- Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism.Pflugers Archiv : European journal of physiology · 2015Article
- Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity.BoneKEy reports · 2015Review
- Links between Vitamin D Deficiency and Cardiovascular Diseases.BioMed research international · 2015Review
- Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.PLoS genetics · 2012Article
- Regulation and function of the FGF23/klotho endocrine pathways.Physiological reviews · 2012Review
- FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Osteo-renal regulation of systemic phosphate metabolism.IUBMB life · 2011Review
- Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease.International journal of nephrology · 2010Article
- Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372.Expert opinion on therapeutic patents · 2010Article
- In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.The Journal of pathology · 2008Article
- Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?Kidney international · 2008Review
- Genetic evidence of serum phosphate-independent functions of FGF-23 on bone.PLoS genetics · 2008Article
- Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2008Article
- The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis.The Journal of endocrinology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe regulation of phosphate homeostasis was thought to be passively mediated by the calciotrophic hormones parathyroid hormone and 1,25(OH)2D3. This article summarizes the emerging trends that show an active regulation of phosphate homeostasis by fibroblast growth factor 23 (FGF-23) - a process fairly independent of calcium homeostasis - and how altered mineral ion metabolism may affect the aging process. RECENT
findingsA major breakthrough in FGF-23 biology has been achieved by the demonstration of strikingly similar physical/biochemical phenotypes of Fgf-23(-/-) and klotho hypomorph mice, which eventually led to the identification of klotho as a cofactor in FGF-23 and its receptor interactions. Furthermore, FGF-23 has emerged as a counter regulator of the renal 1alpha(OH)ase and sodium-phosphate cotransporter activities to modulate phosphate homeostasis. Finally, studies point towards a role of dentine matrix protein 1 in affecting phosphate homeostasis, in coordination with FGF-23. SUMMARY: Recent mouse genetic studies have broadened our understanding of biochemical/molecular pathways involved in phosphate homeostasis, and linked FGF-23 to such regulation. Understanding the molecular interactions of essential calcium and phosphate regulators will enhance our knowledge of the coordinated regulation of mineral ion metabolism, and will help to redefine the molecular pathology of age-associated lesions accompanied by abnormal mineral ion metabolism such as vascular calcifications and osteoporosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.