ArticleAmerican journal of human genetics2007
Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Deciphering the genetic structure of the Quebec founder population using genealogies.European journal of human genetics : EJHG · 2024Article
- Intergenerational caregiving on mental health of middle-aged and older adults in China: empirical insights.Frontiers in public health · 2023Article
- Article
- Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.PLoS genetics · 2016Article
- Correlations in fertility across generations: can low fertility persist?Proceedings. Biological sciences · 2014Article
- Perfect genetic correlation between number of offspring and grandoffspring in an industrialized human population.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cross-national patterns of intergenerational continuities in childbearing in developed countries.Biodemography and social biology · 2013Article
- Article
- Colloquium papers: Heritability of reproductive fitness traits in a human population.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Familial twinning and fertility in Dutch mothers of twins.American journal of medical genetics. Part A · 2008Article
- Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- CFTR mutations and reproductive outcomes in a population isolate.Human genetics · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Reproductive fitness is a complex phenotype that is a direct measure of Darwinian selection. Estimation of the genetic contribution to this phenotype in human populations is confounded by within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. Here, we report an intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility. We introduce an estimator of this correlation that takes into account the presence of multiple parent-offspring pairs from the same nuclear family. Statistical significance of the estimated correlation is assessed by a permutation test that maintains the overall structure of the pedigree. Further, temporal trends in fertility within this population are accounted for. Applying these methods to the S-Leut Hutterites yields a correlation in effective family size of 0.29 between couples and their sons and 0.18 between couples and their daughters, with empirical P<1x10-6 and P=.0041, respectively. Similar results were obtained for completed families (0.31 between couples and their sons and 0.23 between couples and their daughters; empirical P<1x10-6 and P=.00059, respectively). We interpret these results as indicating a significant genetic component to reproductive fitness in the Hutterites.
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