ArticleIntensive care medicine2007
High-frequency oscillatory ventilation reduces lung inflammation: a large-animal 24-h model of respiratory distress.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome.The Cochrane database of systematic reviews · 2016Pooled it
- The effect of high-frequency oscillatory ventilation or airway pressure release ventilation on children with acute respiratory distress syndrome as a rescue therapy.Translational pediatrics · 2020Article
- Effect of high frequency oscillatory ventilation on EVLW and lung capillary permeability of piglets with acute respiratory distress syndrome caused by pulmonary and extrapulmonary insults.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Acute refractory hypoxemia after chest trauma reversed by high-frequency oscillatory ventilation: a case report.Journal of medical case reports · 2013Article
- High-frequency oscillation and tracheal gas insufflation in patients with severe acute respiratory distress syndrome and traumatic brain injury: an interventional physiological study.Critical care (London, England) · 2013Article
- Cerebral gas embolism in a case of Influenza A-associated acute respiratory distress syndrome treated with high-frequency oscillatory ventilation.Annals of thoracic medicine · 2013Article
- Bias flow does not affect ventilation during high-frequency oscillatory ventilation in a pediatric animal model of acute lung injury.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2012Article
- Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep.Anesthesiology · 2010Article
- Open the lung with high-frequency oscillation ventilation or conventional mechanical ventilation? It may not matter!Critical care (London, England) · 2010Review
- A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets.Pediatric research · 2009Article
- Comparison of four methods of lung volume recruitment during high frequency oscillatory ventilation.Intensive care medicine · 2009Article
- Arteriovenous Extracorporeal Lung Assist Allows For Maximization Of Oscillatory Frequencies: A Large-animal Model Of Respiratory Distress.BMC anesthesiology · 2008Article
- Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology.Intensive care medicine · 2008Review
- Understanding high-frequency oscillation: lessons from the animal kingdom.Intensive care medicine · 2007Article
- Comparison between conventional protective mechanical ventilation and high-frequency oscillatory ventilation associated with the prone position.Revista Brasileira de terapia intensivaArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-frequency oscillatory ventilation (HFOV) may reduce ventilator-induced lung injury in experimental neonatal respiratory distress. However, these data permit no conclusions for large animals or adult patients with acute respiratory distress syndrome (ARDS), because in neonates higher frequencies and lower amplitudes can be used, resulting in lower tidal volumes (VT) and airway pressures. The aim of this study was to compare gas exchange, lung histopathology and inflammatory cytokine expression during lung-protective pressure-controlled ventilation (PCV) and HFOV in a long-term large-animal model of ARDS.
designProspective, randomized, controlled pilot study.
settingUniversity animal laboratory. SUBJECTS: Sixteen female pigs (55.3 +/- 3.9 kg).
interventionsAfter induction of ARDS by repeated lavage, the animals were randomly assigned to PCV (VT = 6 ml/kg) and HFOV (6 Hz). After lung injury, a standardised lung recruitment was performed in both groups, and ventilation was continued for 24 h. MEASUREMENTS AND
resultsAfter lung recruitment sustained improvements in the oxygenation index were observed in both groups. The mean airway pressure (mPaw) was significantly lower in the HFOV group during the experiment (p < 0.01). Histologically, lung inflammation was significantly ameliorated in the HFOV group (p < 0.05). The messenger RNA expression of IL-1-beta in lung tissue was significantly lower in the HFOV-treated animals (p < 0.01).
conclusionsThese data suggest that HFOV compared with conventional lung-protective ventilation can reduce lung inflammation in a large-animal 24-h model of ARDS. Furthermore, it was shown that lung recruitment leads to sustained improvements in gas exchange with a significantly lower mPaw when HFOV is used.
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