SynthesisThe journal of headache and pain2007
Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis.
Synthesis in The journal of headache and pain, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Prevalence of familial cluster headache: a systematic review and meta-analysis.The journal of headache and pain · 2020Pooled it
- No Association Between G1246A Polymorphism inFrontiers in genetics · 2020Pooled it
- Neurotransmitter Imbalance in Cluster Headache: A Systematic Review of Mechanisms and Therapeutic Targets.Pain and therapy · 2025Review
- Current Understanding of the Chronobiology of Cluster Headache and the Role of Sleep in Its Management.Nature and science of sleep · 2021Review
- Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.Journal of molecular neuroscience : MN · 2020Article
- Article
- Update on the pathophysiology of cluster headache: imaging and neuropeptide studies.Journal of pain research · 2019Review
- Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.The journal of headache and pain · 2018Article
- Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms.Journal of molecular neuroscience : MN · 2018Article
- Non-Rapid Eye Movement Sleep Parasomnias and Migraine: A Role of Orexinergic Projections.Frontiers in neurology · 2018Article
- A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants.The journal of headache and pain · 2016Article
- Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.Molecular brain · 2015Article
- Neurobiology and sleep disorders in cluster headache.The journal of headache and pain · 2015Review
- Cluster headache: a quasi-rare disorder needing a reappraisal.The journal of headache and pain · 2015Article
- Licit and illicit drug use in cluster headache.Current pain and headache reports · 2014Review
- Genes and primary headaches: discovering new potential therapeutic targets.The journal of headache and pain · 2013Review
- Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.Bioorganic & medicinal chemistry letters · 2013Article
- Pain-related diseases and sleep disorders.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Review
- Genetics of cluster headache.Current pain and headache reports · 2010Review
- Sleep and headache.Seminars in neurology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the association between polymorphisms of the hypocretin receptor 2 gene (HCRTR2) and the risk of cluster headache (CH). The study is a meta-analysis of published case-control studies investigating the association between polymorphisms of the HCRTR2 gene and CH. Pooled odds ratios (OR) were estimated using both random (RE) and fixed effects (FE) models. Three studies, performed in five different European countries, with 593 cases and 599 controls, were included in the study. Allele G of the G1246A HCRTR2 polymorphism was significantly associated with CH (FE OR 1.58, CI 95% 1.27-1.95; RE OR 1.55 (1.14-2.12)). Carriers of the GG genotype showed a higher disease risk compared to the remaining genotypes (FE OR 1.75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.