ReviewExtremophiles : life under extreme conditions2008
The impact of extremophiles on structural genomics (and vice versa).
Review in Extremophiles : life under extreme conditions, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Structure of the NAT10 acetyltransferase and mechanism of tRNA acetylation.Nature communications · 2026Article
- Differential requirement for RecFOR pathway components in Thermus thermophilus.Environmental microbiology reports · 2024Article
- Novel Enzymes From the Red Sea Brine Pools: Current State and Potential.Frontiers in microbiology · 2021Review
- Codon usage clusters correlation: towards protein solubility prediction in heterologous expression systems in E. coli.Scientific reports · 2018Article
- Thermus thermophilus as a Source of Thermostable Lipolytic Enzymes.Microorganisms · 2015Review
- Identification of novel esterase-active enzymes from hot environments by use of the host bacterium Thermus thermophilus.Frontiers in microbiology · 2015Article
- Transferable denitrification capability of Thermus thermophilus.Applied and environmental microbiology · 2014Review
- Thermal unfolding of a mammalian pentameric ligand-gated ion channel proceeds at consecutive, distinct steps.The Journal of biological chemistry · 2013Article
- Identification of a replication initiation protein of the pVV8 plasmid from Thermus thermophilus HB8.Extremophiles : life under extreme conditions · 2013Article
- An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli.PloS one · 2013Article
- Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins.Journal of bacteriology · 2012Article
- Reconstitution of translation from Thermus thermophilus reveals a minimal set of components sufficient for protein synthesis at high temperatures and functional conservation of modern and ancient translation components.Nucleic acids research · 2012Article
- Functional expression of a penicillin acylase from the extreme thermophile Thermus thermophilus HB27 in Escherichia coli.Microbial cell factories · 2012Article
- Genome sequencing of a genetically tractable Pyrococcus furiosus strain reveals a highly dynamic genome.Journal of bacteriology · 2012Article
- Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.Protein science : a publication of the Protein Society · 2012Article
- Thermus thermophilus nucleoside phosphorylases active in the synthesis of nucleoside analogues.Applied and environmental microbiology · 2012Article
- Production and single-step purification of Brugia malayi abundant larval transcript (ALT-2) using hydrophobic interaction chromatography.Journal of industrial microbiology & biotechnology · 2010Article
- Heterologous expression and maturation of an NADP-dependent [NiFe]-hydrogenase: a key enzyme in biofuel production.PloS one · 2010Article
- Overexpression and simple purification of the Thermotoga maritima 6-phosphogluconate dehydrogenase in Escherichia coli and its application for NADPH regeneration.Microbial cell factories · 2009Article
- Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome.Molecular & cellular proteomics : MCP · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of the complete genome sequences of various organisms in the mid-1990s raised the issue of how one could determine the function of hypothetical proteins. While insight might be obtained from a 3D structure, the chances of being able to predict such a structure is limited for the deduced amino acid sequence of any uncharacterized gene. A template for modeling is required, but there was only a low probability of finding a protein closely-related in sequence with an available structure. Thus, in the late 1990s, an international effort known as structural genomics (SG) was initiated, its primary goal to "fill sequence-structure space" by determining the 3D structures of representatives of all known protein families. This was to be achieved mainly by X-ray crystallography and it was estimated that at least 5,000 new structures would be required. While the proteins (genes) for SG have subsequently been derived from hundreds of different organisms, extremophiles and particularly thermophiles have been specifically targeted due to the increased stability and ease of handling of their proteins, relative to those from mesophiles. This review summarizes the significant impact that extremophiles and proteins derived from them have had on SG projects worldwide. To what extent SG has influenced the field of extremophile research is also discussed.
Indexed as
Identifiers
17563834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.