ArticleOncogene2007
The proteasome is involved in determining differential utilization of double-strand break repair pathways.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- Ubiquitin's code: UPS orchestrating DNA repair and genomic stability under genotoxic stress.Molecular and cellular biochemistry · 2026Review
- DSS1 is required for proper Integrator-PP2A function.Nature communications · 2025Article
- Regulatory elements inGenetics in medicine open · 2024Article
- Genome-Wide Association Study of Egg-Laying Traits and Egg Quality in LingKun Chickens.Frontiers in veterinary science · 2022Article
- Guardians of the Genome: BRCA2 and Its Partners.Genes · 2021Review
- Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- DSS1 and ssDNA regulate oligomerization of BRCA2.Nucleic acids research · 2020Article
- PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism.BMC molecular biology · 2019Article
- Proteasome Structure and Assembly.Journal of molecular biology · 2017Review
- RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.DNA repair · 2016Article
- Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis.Scientific reports · 2016Article
- Exploring Mouse Protein Function via Multiple Approaches.PloS one · 2016Article
- Review
- The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.Molecular cell · 2014Article
- Gene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine Tumours.Journal of Cancer · 2014Article
- BRCA2: one small step for DNA repair, one giant protein purified.The Yale journal of biology and medicine · 2013Review
- Article
- The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.The EMBO journal · 2012Article
- Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.Cell cycle (Georgetown, Tex.) · 2011Article
- Destroying the ring: Freeing DNA from Ku with ubiquitin.FEBS letters · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The DSS1 protein interacts with the breast cancer susceptibility protein BRCA2 that plays an integral role in the repair of DNA double-strand breaks (DSBs). DSS1 has also been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells. This raises the possibility of functional interplay between the DNA repair machinery and the proteasome. We show here that human DSS1 interacts with the RPN3 and RPN7 proteasome subunits and define regions of DSS1 important for the interactions with RPN3, RPN7 and BRCA2. We also show that BRCA2 interacts with RPN3 and RPN7 and that the BRCA2/RPN7 interaction is independent of DSS1. Finally, and most significantly, we demonstrate that the proteolytic activity of the proteasome is a determinant of the choice of DSB repair pathway; inhibition of proteasome proteolytic activity results in an increase in the utilization of potentially mutagenic single-strand annealing at the expense of a reduction in the level of error-free gene conversion. This confirms a functional link between DSB repair and proteasomal activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.