ArticleProceedings of the National Academy of Sciences of the United States of America2007
The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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97 citing papers in PubMed, 270 citations in OpenAlex.
- Cellular aspects of NaQuantitative plant biology · 2026Review
- Cellular pH homeostasis shapes root system architecture by modulating auxin-mediated developmental responses.Plant physiology · 2025Article
- The Potassium Utilization Gene Network inInternational journal of molecular sciences · 2025Article
- Potassium homeostasis and signalling: from the whole plant to the subcellular level.Quantitative plant biology · 2025Review
- Potassium extrusion by plant cells: evolution from an emergency valve to a driver of long-distance transport.The New phytologist · 2025Review
- Functional Characterization of the 14-3-3 Gene Family in Alfalfa and the Role ofInternational journal of molecular sciences · 2024Article
- The vacuolar KScience advances · 2024Article
- Understanding the mechanobiology of phytoacoustics through molecular Lens: Mechanisms and future perspectives.Journal of advanced research · 2024Review
- A charged existence: A century of transmembrane ion transport in plants.Plant physiology · 2024Review
- Investigation of two-pore KHeliyon · 2024Article
- Comparative transcriptome analysis reveals the adaptive mechanisms of halophyteFrontiers in plant science · 2024Article
- Ion Changes and Signaling under Salt Stress in Wheat and Other Important Crops.Plants (Basel, Switzerland) · 2023Review
- Review
- Transcriptome, Biochemical and Phenotypic Analysis of the Effects of a Precision Engineered Biostimulant for Inducing Salinity Stress Tolerance in Tomato.International journal of molecular sciences · 2023Article
- Potassium nutrient status drives posttranslational regulation of a low-K response network in Arabidopsis.Nature communications · 2023Article
- Article
- Reducing potassium deficiency by using sodium fertilisation.Stress biology · 2022Review
- Overdominant expression of related genes of ion homeostasis improves KBMC plant biology · 2022Article
- Abiotic stress responses in plants.Nature reviews. Genetics · 2022Review
- A glossary of plant cell structures: Current insights and future questions.The Plant cell · 2022Review
37 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis thaliana genome contains five genes that encode two pore K+ (TPK) channels. The most abundantly expressed isoform of this family, TPK1, is expressed at the tonoplast where it mediates K+ -selective currents between cytoplasmic and vacuolar compartments. TPK1 open probability depends on both cytoplasmic Ca2+ and cytoplasmic pH but not on the tonoplast membrane voltage. The channel shows intrinsic rectification and can be blocked by Ba2+, tetraethylammonium, and quinine. TPK1 current was found in all shoot cell types and shows all of the hallmarks of the previously described vacuolar K (VK) tonoplast channel characterized in guard cells. Characterization of TPK1 loss-of-function mutants and TPK1-overexpressing plants shows that TPK1 has a role in intracellular K+ homeostasis affecting seedling growth at high and low ambient K+ levels. In stomata, TPK1 function is consistent with vacuolar K+ release, and removal of this channel leads to slower stomatal closure kinetics. During germination, TPK1 contributes to the radicle development through vacuolar K+ deposition to provide expansion growth or in the redistribution of essential minerals.
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