ArticleMolecular and cellular biology2007
Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation.Human molecular genetics · 2025Article
- Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation.bioRxiv : the preprint server for biology · 2025Article
- Article
- A novel transgenic Cre allele to label mouse cardiac conduction system.Developmental biology · 2021Article
- A PITX2 splice-site mutation in a family with Axenfeld-Rieger syndrome leads to decreased expression of nuclear PITX2 protein.International ophthalmology · 2021Article
- A novel frameshift mutation in the PITX2 gene in a family with Axenfeld-Rieger syndrome using targeted exome sequencing.BMC medical genetics · 2019Article
- Genetic regulation of murine pituitary development.Journal of molecular endocrinology · 2015Review
- PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex.Biochemical and biophysical research communications · 2014Article
- PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer.Clinical & experimental metastasis · 2014Article
- FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of mitogen-activated protein kinase (MAPK) signaling pathway.The Journal of biological chemistry · 2014Article
- Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma.Molecular and cellular biochemistry · 2013Article
- Wnt/β-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3.The Journal of biological chemistry · 2013Article
- TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression.Oncogene · 2011Article
- Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2.Investigative ophthalmology & visual science · 2011Article
- Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.BMC developmental biology · 2010Article
- Insulin represses transcription of the thyroid stimulating hormone beta-subunit gene through increased recruitment of nuclear factor I.The Journal of biological chemistry · 2010Article
- Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Proteomic and genomic analysis of PITX2 interacting and regulating networks.FEBS letters · 2009Article
- TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.Developmental biology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pitx2, a paired-related homeobox gene that is mutated in Rieger syndrome I, is the earliest known marker of oral ectoderm. Pitx2 was previously shown to be required for tooth, palate, and pituitary development in mice; however, the mechanisms regulating Pitx2 transcription in the oral ectoderm are poorly understood. Here we used an in vivo transgenic approach to investigate the mechanisms regulating Pitx2 transcription. We identified a 7-kb fragment that directs LacZ expression in oral ectoderm and in many of its derivatives. Deletion analysis of transgenic embryos reduced this fragment to a 520-bp region that directed LacZ activity to Rathke's pouch. A comparison of the mouse and human sequences revealed a conserved nuclear factor 1 (NF-1) recognition element near a consensus T-cell factor (TCF)/LEF binding site. The mutation of either site individually abolished LacZ activity in transgenic embryos, identifying Pitx2 as a direct target of Wnt signaling in pituitary development. These findings uncover a requirement for NF-1 and TCF factors in Pitx2 transcriptional regulation in the pituitary and provide insight into the mechanisms controlling region-specific transcription in the oral ectoderm and its derivatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.