ArticleAntimicrobial agents and chemotherapy2007
Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Antibiotics targeting bacterial ribosomal subunit biogenesis.The Journal of antimicrobial chemotherapy · 2020Review
- An Open Label, Multi-Center, Non-Interventional Post-Marketing Surveillance to Monitor the Safety and Efficacy of ALTARGO® (Retapamulin) Administered in Korean Patients According to the Prescribing Information.Annals of dermatology · 2018Article
- In Vitro Activity of Retapamulin and Antimicrobial Susceptibility Patterns in a Longitudinal Collection of Methicillin-Resistant Staphylococcus aureus Isolates from a Veterans Affairs Medical Center.Antimicrobial agents and chemotherapy · 2015Article
- Prevention of Recurrent Staphylococcal Skin Infections.Infectious disease clinics of North America · 2015Review
- Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children.Antimicrobial agents and chemotherapy · 2014Article
- Article
- Inhibition of ribosomal subunit synthesis in Escherichia coli by the vanadyl ribonucleoside complex.Current microbiology · 2013Article
- Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.Antimicrobial agents and chemotherapy · 2013Article
- The vanadyl ribonucleoside complex inhibits ribosomal subunit formation in Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2012Article
- Cutaneous infections and infestations: new therapies.The Journal of clinical and aesthetic dermatology · 2011Article
- Erythromycin- and chloramphenicol-induced ribosomal assembly defects are secondary effects of protein synthesis inhibition.Antimicrobial agents and chemotherapy · 2009Article
- Current and novel antibiotics against resistant Gram-positive bacteria.Infection and drug resistance · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.