ArticleInternational journal of hematology2007
Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells.
Article in International journal of hematology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- In vitro large scale production of human mature red blood cells from hematopoietic stem cells by coculturing with human fetal liver stromal cells.BioMed research international · 2013Trial
- Progresses in overcoming the limitations of in vitro erythropoiesis using human induced pluripotent stem cells.Stem cell research & therapy · 2024Review
- Review
- Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials.Cell regeneration (London, England) · 2021Article
- Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation.International journal of stem cells · 2020Article
- Mosaicism of an ELANE Mutation in an Asymptomatic Mother.Journal of clinical immunology · 2019Article
- Article
- Article
- Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.Leukemia · 2014Article
- Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells.Stem cell research & therapy · 2013Review
- Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Generation of red blood cells from human embryonic/induced pluripotent stem cells for blood transfusion.International journal of hematology · 2012Review
- Human fetal liver stromal cells expressing erythropoietin promote hematopoietic development from human embryonic stem cells.Cellular reprogramming · 2012Article
- Hybrid cells differentiate to hepatic lineage cells and repair oxidative damage.Cellular & molecular biology letters · 2010Article
- Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.Blood · 2010Article
- Efficient method for generating nuclear fractions from marrow stromal cells.Cytotechnology · 2008Article
- Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Controlled differentiation of stem cells.Advanced drug delivery reviews · 2008Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a novel method for the efficient production of hematopoietic progenitors from human embryonic stem cells (hESC) via coculture with murine fetal liver-derived stromal cells, in which embryonic hematopoiesis dramatically expands at midgestation. We generated various hematopoietic progenitors in coculture, and this hematopoietic activity was concentrated in cobblestone-like cells derived from differentiated hESC. The cobblestone-like cells mostly expressed CD34 and retained an endothelial cell potential. They also contained hematopoietic colony-forming cells, especially erythroid and multilineage colony-forming cells at high frequency. The multipotential hematopoietic progenitors abundant among the cobblestone-like cells produced almost all types of mature blood cells, including adult-type alpha-globin-expressing erythrocytes and tryptase/chymase double-positive mast cells. These progenitors showed neither the immature properties of ESC nor the potential to differentiate into endoderm and ectoderm at a clonal level. The coculture system developed for hESC can provide a novel source of hematopoietic and blood cells for applications in cellular therapy and drug screening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.