Evidence map›Paper›PMID 17562578›Full record

ReviewChild and adolescent psychiatric clinics of North America2007

Molecular basis of genetic neuropsychiatric disorders.

Deepa V Venkitaramani, Paul J Lombroso

Abstract readReview
In one paragraph

Review in Child and adolescent psychiatric clinics of North America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Deepa V VenkitaramaniChild Study Center, SHM I-270, Yale University School of Medicine, New Haven, CT 06520, USA.
Paul J Lombroso

Funding

STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPSK02MH001527 · NIMH · YALE UNIVERSITY · PI LOMBROSO, PAUL J · 1998 to 2008
$926k
NIMH NIH HHS K02 MH001527NIMH NIH HHS MH01527
6 · The paper itself

Abstract

The past decade has seen tremendous advances in our understanding of the molecular and genetic basis of many neuropsychiatric disorders. Although the genetic aberrations that lead to these syndromes have been identified in many cases, not much is known about specific gene products and their function. This article reviews the molecular basis of well-known neurogenetic disorders. The syndromes discussed here follow a Mendelian pattern of inheritance and are predominantly single-gene disorders; however, most childhood and adolescent psychiatric disorders are polygenic in nature. This genetic complexity and heterogeneity has made it difficult to identify the genes involved in their etiology. Identification of genetic and environmental risk factors involved in the etiology of complex disorders, such as autism, will help in the discovery of medications that can ameliorate the symptoms.

Indexed as

Angelman SyndromeBrainChromosomes, Human, XHumansIntellectual DisabilityMental DisordersPrader-Willi Syndrome

Identifiers

PMID17562578
PMCPMC2734465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.