ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2007
Retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: long-term results.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Perfluorocarbon liquid assisted large retinal epithelium patching in sub-macular hemorrhage secondary to age related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Trial
- iPSC-RPE in Retinal Degeneration: Recent Advancements and Future Perspectives.Cold Spring Harbor perspectives in medicine · 2023Review
- Retina stem cells, hopes and obstacles.World journal of stem cells · 2021Review
- Pluripotent stem cell therapy for retinal diseases.Annals of translational medicine · 2021Review
- Trends of Stem Cell Therapies in Age-Related Macular Degeneration.Journal of clinical medicine · 2021Review
- Long-term clinical outcomes of submacular blood removal with isolated autologous retinal pigment epithelium-choroid patch graft transplantation in long-standing large-sized submacular hematomas: An Indian experience.Indian journal of ophthalmology · 2020Article
- Retinal stem cell transplantation: Balancing safety and potential.Progress in retinal and eye research · 2020Review
- Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part II: Cell and Tissue Engineering Therapies.Frontiers in bioengineering and biotechnology · 2020Review
- Autologous full-thickness RPE-choroid graft to treat high-risk drusenoid pigment epithelial detachment without CNV.GMS ophthalmology cases · 2020Article
- Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.Stem cells translational medicine · 2019Article
- COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS.Retina (Philadelphia, Pa.) · 2018Article
- OCT angiography documented reperfusion of translocated autologous full thickness RPE-choroid graft for complicated neovascular age-related macular degeneration.Eye (London, England) · 2017Article
- Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.Scientific reports · 2015Article
- Regenerating Retinal Pigment Epithelial Cells to Cure Blindness: A Road Towards Personalized Artificial Tissue.Current stem cell reports · 2015Article
- Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT.Translational vision science & technology · 2015Article
- 25th RCOphth Congress, President's Session paper: 25 years of progress in vitreoretinal surgery.Eye (London, England) · 2014Review
- A pedicled autologous choroid RPE patch: a technique to preserve perfusion.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2012Article
- [Subretinal surgery for massive hemorrhage].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2012Article
- Ophthalmic transplantology: posterior segment of the eye--part II.Medical science monitor : international medical journal of experimental and clinical research · 2012Review
- Emerging options for the management of age-related macular degeneration with stem cells.Stem cells and cloning : advances and applications · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo study the results of the translocation of a free autologous retinal pigment epithelium (RPE)-choroid graft after removal of a subfoveal choroidal neovascular membrane in patients with exudative age-related macular degeneration (AMD), and to determine whether preoperative variables may predict visual outcome at 1 year after surgery.
methodsProspective interventional case series of 84 eyes of 83 consecutive eligible patients with exudative AMD with a minimal follow-up of 1 year after surgery. Of this group, 45, 24 and 11 patients reached a follow-up of respectively 2, 3 and 4 years. Pre- and postoperative evaluation included ETDRS visual acuity (VA), fixation testing and color fundus photography. Preoperative fluorescein angiograms were assessed by masked readers for lesion size, size of hemorrhage and lesion composition according to the MPS criteria. The relationship between lesion composition adjusted for preoperative delay and VA, lesion size, percentage of blood, and visual outcome at 1 year after surgery was analyzed.
resultsThe mean VA (logMAR) improved slightly at 1 and 2 years (0.89, Delta = -0.06), 3 years (0.79, Delta = -0.16) and 4 years (0.74, Delta = -0.21) after surgery. Five patients had a preoperative VA better than 20/80, compared to 19 out of 84, six out of 45, four out of 24 and two out of 11 after 1, 2, 3 and 4 years respectively. Fixation was located on the graft in 62 patients (74%) up to the last examination. Predominantly classic and occult lesions had a significant better prognosis than minimally classic or hemorrhagic (> or = 50% blood) lesions. Retinal detachment occurred in seven patients; two caused by rhegmatogenous detachment and five caused by proliferative vitreoretinopathy. In 11 eyes, a recurrent or persisting neovascular membrane was observed.
conclusionAn autologous free RPE-choroid graft may stabilize or improve vision in patients with exudative AMD up to 4 years after surgery.
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17562066What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.