ArticleBMC infectious diseases2007
Innate immunity glycoprotein gp-340 variants may modulate human susceptibility to dental caries.
Article in BMC infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Balancing selection at the human salivary agglutinin gene (iScience · 2022Article
- Dissecting the Role of VicK Phosphatase in Aggregation and Biofilm Formation ofJournal of dental research · 2021Article
- Efficient ammonia production from food by-products by engineered Escherichia coli.AMB Express · 2020Article
- Oral antimicrobial activity weakened in children with electronic waste lead exposure.Environmental science and pollution research international · 2020Article
- Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.Life science alliance · 2020Article
- The Multifaceted Nature of Streptococcal Antigen I/II Proteins in Colonization and Disease Pathogenesis.Frontiers in microbiology · 2020Review
- Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.EBioMedicine · 2017Article
- Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development.EBioMedicine · 2017Article
- Streptococcus mutans, Streptococcus sobrinus and Candida albicans in oral samples from caries-free and caries-active children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2016Article
- Investigation of the N-terminal coding region ofBalkan journal of medical genetics : BJMG · 2016Article
- SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces.Frontiers in immunology · 2016Review
- Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Oral microbial profile discriminates breast-fed from formula-fed infants.Journal of pediatric gastroenterology and nutrition · 2013Article
- Host and bacterial phenotype variation in adhesion of Streptococcus mutans to matched human hosts.Infection and immunity · 2012Article
- Durable bonds at the adhesive/dentin interface: an impossible mission or simply a moving target?Brazilian dental science · 2012Article
- Stick to your gums: mechanisms of oral microbial adherence.Journal of dental research · 2011Review
- Virulence mechanisms of Tannerella forsythia.Periodontology 2000 · 2010Review
- The changing faces of Streptococcus antigen I/II polypeptide family adhesins.Molecular microbiology · 2010Review
- Snacking habits and caries in young children.Caries research · 2010Article
- Improved ability of biological and previous caries multimarkers to predict caries disease as revealed by multivariate PLS modelling.BMC oral health · 2009Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundBacterial adhesion is an important determinant of colonization and infection, including dental caries. The salivary scavenger receptor cysteine-rich glycoprotein gp-340, which mediates adhesion of Streptococcus mutans (implicated in caries), harbours three major size variants, designated gp-340 I to III, each specific to an individual saliva. Here we have examined the association of the gp-340 I to III polymorphisms with caries experience and adhesion of S. mutans.
methodsA case-referent study was performed in 12-year-old Swedish children with high (n = 19) or low (n = 19) caries experiences. We measured the gp-340 I to III saliva phenotypes and correlated those with multiple outcome measures for caries experience and saliva adhesion of S. mutans using the partial least squares (PLS) multivariate projection technique. In addition, we used traditional statistics and 2-year caries increment to verify the established PLS associations, and bacterial adhesion to purified gp-340 I to III proteins to support possible mechanisms.
resultsAll except one subject were typed as gp-340 I to III (10, 23 and 4, respectively). The gp-340 I phenotype correlated positively with caries experience (VIP = 1.37) and saliva adhesion of S. mutans Ingbritt (VIP = 1.47). The gp-340 II and III phenotypes tended to behave in the opposite way. Moreover, the gp-340 I phenotype tended to show an increased 2-year caries increment compared to phenotypes II/III. Purified gp-340 I protein mediated markedly higher adhesion of S. mutans strains Ingbritt and NG8 and Lactococcus lactis expressing AgI/II adhesins (SpaP or PAc) compared to gp-340 II and III proteins. In addition, the gp-340 I protein appeared over represented in subjects positive for Db, an allelic acidic PRP variant associated with caries, and subjects positive for both gp-340 I and Db tended to experience more caries than those negative for both proteins.
conclusionGp-340 I behaves as a caries susceptibility protein.
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