Trial reportBone2007
Pamidronate preserves bone mass for at least 2 years following acute administration for pediatric burn injury.
Trial report in Bone, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02074631 (Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bisphosphonate treatment for secondary osteoporosis in children, youth, and young adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Trial
- Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.Annals of surgery · 2016Trial
- FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL.Shock (Augusta, Ga.) · 2016Trial
- The effect of burn on serum concentrations of sclerostin and FGF23.Burns : journal of the International Society for Burn Injuries · 2015Trial
- Pamidronate attenuates muscle loss after pediatric burn injury.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Trial
- Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy.Journal of the American College of Surgeons · 2012Trial
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Pharmacologic Treatments to Preserve Bone and Muscle Mass in Osteosarcopenia.Current osteoporosis reports · 2020Review
- Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients.Frontiers in endocrinology · 2019Article
- Bone metabolism in pediatric burned patients: A review.Burns : journal of the International Society for Burn Injuries · 2018Review
- The Long-Term Impact of Severe Burn Trauma on Musculoskeletal Health.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- The Role of Calcium in Inflammation-Associated Bone Resorption.Biomolecules · 2018Review
- GLUCOCORTICOID EXCESS IN BONE AND MUSCLE.Clinical reviews in bone and mineral metabolism · 2018Article
- The Role of Bone Secreted Factors in Burn-Induced Muscle Cachexia.Current osteoporosis reports · 2018Review
- The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Optimal Nutrition for Acute Rehabilitation in the PICU.Journal of pediatric intensive care · 2015Review
- Disruption of bone and skeletal muscle in severe burns.Bone research · 2015Review
- Preliminary evidence of early bone resorption in a sheep model of acute burn injury: an observational study.Journal of bone and mineral metabolism · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We have previously shown that pamidronate, when given within 10 days of burn injury, preserves lumbar spine bone mineral content from admission to discharge in 6-8 weeks and at 6 months increases both lumbar spine and total body bone mineral content (BMC) over placebo. We followed patients unblinded after 6 months every 3 months up to 2 years post-burn to see if the effects of pamidronate were sustained. Additionally, we assessed bone remodeling at 1 year post-burn by iliac crest bone biopsy. We enrolled 57 subjects who were initially randomized to pamidronate (n=32) and placebo (n=25). After 2 years, 21 subjects (pamidronate=8, placebo=13) remained. Analysis of bone densitometry by dual energy X-ray absorptiometry revealed an effect of both treatment (p<0.012 for total body BMC, p<0.001 for lumbar spine BMC, p<0.014 for lumbar spine bone area and p<0.003 for lumbar spine bone density (BMD)) and time (p<0.0003 on total body BMC, p<0.001 on lumbar spine BMC, p<0.001 on lumbar spine bone area, and no significant difference on lumbar spine BMD). There was no interaction between treatment and time. Results for bone histomorphometry revealed no effect of treatment on either static or dynamic parameters but did show an effect of time on osteoid area (p=0.004, surface p<0.001, and width, p<0.001). We conclude that acute administration of pamidronate resulted in sustained therapeutic effect on bone and that this type of administration may serve as a useful adjunct to other therapies in the preservation and augmentation of bone mass following severe burns.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.