ArticleNeurobiology of disease2007
Neuroanatomical substrates for paroxysmal dyskinesia in lethargic mice.
Article in Neurobiology of disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Discovery of the First Selective MACS pharmacology & translational science · 2021Article
- Dystonia and Cerebellum: From Bench to Bedside.Life (Basel, Switzerland) · 2021Review
- Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction.Frontiers in cellular neuroscience · 2018Article
- A new knock-in mouse model of l-DOPA-responsive dystonia.Brain : a journal of neurology · 2015Article
- Dystonia and cerebellar degeneration in the leaner mouse mutant.Brain research · 2015Article
- Stress, caffeine and ethanol trigger transient neurological dysfunction through shared mechanisms in a mouse calcium channelopathy.Neurobiology of disease · 2013Article
- Limited regional cerebellar dysfunction induces focal dystonia in mice.Neurobiology of disease · 2013Article
- Purkinje cell-specific ablation of Cav2.1 channels is sufficient to cause cerebellar ataxia in mice.Cerebellum (London, England) · 2012Article
- Convergent mechanisms in etiologically-diverse dystonias.Expert opinion on therapeutic targets · 2011Review
- Animal models of dystonia: Lessons from a mutant rat.Neurobiology of disease · 2011Review
- The basal ganglia and cerebellum interact in the expression of dystonic movement.Brain : a journal of neurology · 2008Article
- Paroxysmal dyskinesias in mice.Movement disorders : official journal of the Movement Disorder Society · 2008Article
- Experimental Models of Absence Epilepsy.Basic and clinical neuroscienceReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The paroxysmal dyskinesias are a group of neurological disorders described by intermittent attacks of involuntary abnormal movements superimposed on a relatively normal baseline. The neuroanatomical substrates for these attacks are not fully understood, though available evidence from studies of affected people and animal models points to dysfunction in the basal ganglia or cerebellum. In the current studies, the anatomical basis for paroxysmal dyskinesias in lethargic mice was determined via histochemical methods sensitive to changes in regional brain activity followed by surgical elimination of the suspected source. Cytochrome oxidase histochemistry revealed increased activity in the red nucleus. Surgical removal of the cerebellum worsened ataxia but eliminated paroxysmal dyskinesias. These studies support the hypothesis that abnormal cerebellar output contributes to paroxysmal dyskinesias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.