ArticleBiomaterials2007
The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 103 citations in OpenAlex.
- Surgical site infections following colorectal cancer surgery: a randomized prospective trial comparing common and advanced antimicrobial dressing containing ionic silver.World journal of surgical oncology · 2012Trial
- A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Molecular modeling study of micro and nanocurcumin with in vitro and in vivo antibacterial validation.Scientific reports · 2023Article
- Absorption and Resonance Rayleigh Scattering Spectra of Ag(I) and Erythrosin System and Their Analytical Application in Food Safety.Frontiers in nutrition · 2022Article
- Investigating the Impact of Collagen-Chitosan Derived fromRegenerative therapy · 2021Article
- Effect of Ethylene Oxide Sterilization on Polyvinyl Alcohol Hydrogel Compared with Gamma Radiation.Tissue engineering. Part A · 2020Article
- In Vivo Evaluation of the Wound Healing Activity of Extracts and Bioactive Constituents of the Marine IsopodMarine drugs · 2020Article
- Comprehensive Assessment of Nile Tilapia Skin (Marine drugs · 2020Article
- Skin tissue regeneration for burn injury.Stem cell research & therapy · 2019Review
- Antibacterial Effect of Curcumin against Clinically IsolatedBioMed research international · 2019Article
- Luminal Plasma Treatment for Small Diameter Polyvinyl Alcohol Tubular Scaffolds.Frontiers in bioengineering and biotechnology · 2019Article
- Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring.Stem cell research & therapy · 2017Article
- Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds.Cell transplantation · 2017Article
- The Effect of Silver Nanoparticles on Wounds Contaminated withIranian journal of pharmaceutical research : IJPR · 2017Article
- Effects of silver nanoparticles onVeterinary research forum : an international quarterly journal · 2017Article
- Silver containing hydrofiber dressing promotes wound healing in paediatric patients with partial thickness burns.Pediatric surgery international · 2016Article
- Effect of Platelet Rich Plasma Combined with Chitosan Biodegradable Film on Full-Thickness Wound Healing in Rat Model.Bulletin of emergency and trauma · 2016Article
- Infected animal models for tissue engineering.Methods (San Diego, Calif.) · 2015Review
- Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries.Oncotarget · 2015Article
- Tilapia Piscidin 4 (TP4) Stimulates Cell Proliferation and Wound Closure in MRSA-Infected Wounds in Mice.Marine drugs · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We determined whether a two-part space-conforming polyethylene glycol/dopa polymer-based gel promoted healing of contaminated wounds in mice. This silver-catalysed gel was previously developed to be broadly microbiocidal in vitro while being biocompatible with human wound cell functioning. Full-thickness wounds were created on the backs of mice. The wounds were inoculated with 10(4) CFU of each of four common skin wound contaminants, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumanii and Clostridium perfringens. The wounds were then treated with our multifunctional polymer-based gel, the commercially available NewSkin product, or left to heal untreated. The untreated wounds were overtly infected, and presented detectable bacterial loads over the entire 21-day healing period, while the gel and NewSkin groups presented significantly smaller rises in bacterial levels and were cleared of detectable colonies by the third week, with the gel group clearing the bacteria earlier. While all three groups healed their wounds, the polymer-based gel-treated group demonstrated significantly earlier re-epithelialization and dermal maturation (P<0.05). This was reflected in a quick regain of tensile strength. This accelerated dermal maturation and regain in strength was noted in mice treated with the polymer-based gel when compared to wound treated with the commercially available Aquacel-Ag dressing (P<0.05). What distinguishes the polymer-based gel from these other products is that it is incorporated within the healing wound. These preclinical studies show that the anti-microbial polymer gel not only supports but also accelerates healing of bacterially contaminated wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.