ArticleFree radical biology & medicine2007
Nox regulation of smooth muscle contraction.
Article in Free radical biology & medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- Assessing target genes for homing suppression gene drive.The EMBO journal · 2026Article
- Astrocyte-to-neuron HNature metabolism · 2025Article
- Orthologs of NOX5 and EC-SOD/SOD3: dNox and dSod3 Impact Egg Hardening Process and Egg Laying in Reproductive Function ofInternational journal of molecular sciences · 2024Article
- Finishing the egg.Genetics · 2024Article
- She's got nerve: roles of octopamine in insect female reproduction.Journal of neurogenetics · 2021Review
- "Urate and NOX5 Control Blood Digestion in the Hematophagous InsectFrontiers in physiology · 2021Article
- Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells.Scientific reports · 2020Article
- Article
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- NOX5: Molecular biology and pathophysiology.Experimental physiology · 2019Review
- Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease.Antioxidants & redox signaling · 2019Review
- NADPH oxidase-generated reactive oxygen species in mature follicles are essential forProceedings of the National Academy of Sciences of the United States of America · 2018Article
- NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function.Journal of the American Heart Association · 2018Article
- Stress-induced reproductive arrest in Drosophila occurs through ETH deficiency-mediated suppression of oogenesis and ovulation.BMC biology · 2018Article
- The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling.PLoS genetics · 2017Article
- Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase.BMC evolutionary biology · 2017Article
- Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5.Frontiers in physiology · 2016Article
- Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs.PloS one · 2013Article
- Molecular cloning and functional characterization of the dual oxidase (BmDuox) gene from the silkworm Bombyx mori.PloS one · 2013Article
- Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.Chemistry & biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The catalytic subunit gp91phox (Nox2) of the NADPH oxidase of mammalian phagocytes is activated by microbes and immune mediators to produce large amounts of reactive oxygen species (ROS) which participate in microbial killing. Homologs of gp91phox, the Nox and Duox enzymes, were recently described in a range of organisms, including plants, vertebrates, and invertebrates such as Drosophila melanogaster. While their enzymology and cell biology are being extensively studied in many laboratories, little is known about in vivo functions of Noxes. Here, we establish and use an inducible system for RNAi to discover functions of dNox, an ortholog of human Nox5 in Drosophila. We report here that depletion of dNox in musculature causes retention of mature eggs within ovaries, leading to female sterility. In dNox-depleted ovaries and ovaries treated with a Nox inhibitor, muscular contractions induced by the neuropeptide proctolin are markedly inhibited. This functional defect results from a requirement for dNox-for the proctolin-induced calcium flux in Drosophila ovaries. Thus, these studies demonstrate a novel biological role for Nox-generated ROS in mediating agonist-induced calcium flux and smooth muscle contraction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.