ArticleBiomaterials2007
Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Nanoparticle delivery ofScience advances · 2022Article
- Interaction of Poly(l-lysine)/Polysaccharide Complex Nanoparticles with Human Vascular Endothelial Cells.Nanomaterials (Basel, Switzerland) · 2018Article
- Interaction between immobilized polyelectrolyte complex nanoparticles and human mesenchymal stromal cells.International journal of nanomedicine · 2014Article
- pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents.Polymer international · 2012Article
- Effective non-viral delivery of siRNA to acute myeloid leukemia cells with lipid-substituted polyethylenimines.PloS one · 2012Article
- Gold nanoparticles delivery in mammalian live cells: a critical review.Nano reviews · 2010Article
- Nanoparticles for biomedical imaging.Expert opinion on drug delivery · 2009Review
- Quantitative mechanics of endothelial phagocytosis of silicon microparticles.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2009Article
- Nanovehicular intracellular delivery systems.Journal of pharmaceutical sciences · 2008Review
- Multifunctional nanoparticulate polyelectrolyte complexes.Pharmaceutical research · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A non-toxic, nanoparticulate polyelectrolyte complex (PEC) drug delivery system was formulated to maintain suitable physicochemical properties at physiological pH. Toxicity, binding, and internalization were evaluated in relevant microvascular endothelial cells. PEC were non-toxic, as indicated by cell proliferation studies and propidium iodide staining. Inhibitor studies revealed that PEC were bound, in part, via heparan sulfate proteoglycans and internalized through macropinocytosis. A novel, flow cytometric, Scatchard protocol was established and showed that PEC, in the absence of surface modification, bind cells non-specifically with positive cooperativity, as seen by graphical transformations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.