ArticleJournal of theoretical biology2007
A mathematical model of fluid secretion from a parotid acinar cell.
Article in Journal of theoretical biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Interdependence of cytosolic and mitochondrial calcium dynamics in a hepatocyte cell due to obesity.Journal of biosciences · 2026Article
- A Mathematical Exploration of SDH-b Loss in Chromaffin Cells.Bulletin of mathematical biology · 2025Article
- The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland.iScience · 2025Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- Modeling of CaBBA advances · 2021Article
- Fluid and solute transport across the retinal pigment epithelium: a theoretical model.Journal of the Royal Society, Interface · 2020Article
- Wet-tip versus dry-tip regimes of osmotically driven fluid flow.Scientific reports · 2019Article
- A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.Bulletin of mathematical biology · 2019Article
- A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion.Bulletin of mathematical biology · 2018Article
- Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle.eLife · 2018Article
- Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.Journal of theoretical biology · 2017Article
- Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- A mathematical model of calcium dynamics in HSY cells.PLoS computational biology · 2017Article
- Mitotic cell rounding and epithelial thinning regulate lumen growth and shape.Nature communications · 2015Article
- Multiscale modelling of saliva secretion.Mathematical biosciences · 2014Article
- Modelling mechanism of calcium oscillations in pancreatic acinar cells.Journal of bioenergetics and biomembranes · 2014Article
- Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.Journal of biosciences · 2014Article
- Response to "What do aquaporin knockout studies tell us about fluid transport in epithelia?" Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297-305.The Journal of membrane biology · 2013Article
- Model discrimination in dynamic molecular systems: application to parotid de-differentiation network.Journal of computational biology : a journal of computational molecular cell biology · 2013Article
- What do aquaporin knockout studies tell us about fluid transport in epithelia?The Journal of membrane biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Salivary fluid secretion is crucial for preventing problems such as dryness of mouth, difficulty with mastication and swallowing, as well as oral pain and dental cavities. Fluid flow is driven primarily by the transepithelial movement of chloride and sodium ions into the parotid acinus lumen. The activation of Cl(-) channels is calcium dependent, with the average elevated calcium concentration during calcium oscillations increasing the conductance of the channels, leading to an outflow of Cl(-). The accumulation of NaCl in the lumen drives water flow by osmosis. We construct a mathematical model of the calcium concentration oscillations and couple this to a model for Cl(-) efflux. We also construct a model governing fluid flow in an isolated parotid acinar cell, which includes a description of the rate of change of intracellular ion concentrations, cell volume, membrane potential and water flow rate. We find that [Ca(2+)] oscillations lead to oscillations in fluid flow, and that the rate of fluid flow is regulated by the average calcium concentration and not the frequency of the oscillations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.