ArticleTheoretical biology & medical modelling2007
Lens stem cells may reside outside the lens capsule: an hypothesis.
Article in Theoretical biology & medical modelling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- A zebrafish model ofFrontiers in cell and developmental biology · 2025Article
- A new eye lens structure associated with capsule/basement membrane growth.microPublication biology · 2024Article
- Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment.Bioengineering (Basel, Switzerland) · 2021Review
- Lens regeneration: scientific discoveries and clinical possibilities.Molecular biology reports · 2021Review
- Importance of the stem cell microenvironment for ophthalmological cell-based therapy.World journal of stem cells · 2015Review
- The penny pusher: a cellular model of lens growth.Investigative ophthalmology & visual science · 2014Article
- Ocular stem cells: a status update!Stem cell research & therapy · 2014Review
- Review: corneal epithelial stem cells, their niche and wound healing.Molecular vision · 2013Review
- The lens epithelium: focus on the expression and function of the alpha-crystallin chaperones.The international journal of biochemistry & cell biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we consider the ocular lens in the context of contemporary developments in biological ideas. We attempt to reconcile lens biology with stem cell concepts and a dearth of lens tumors.Historically, the lens has been viewed as a closed system, in which cells at the periphery of the lens epithelium differentiate into fiber cells. Theoretical considerations led us to question whether the intracapsular lens is indeed self-contained. Since stem cells generate tumors and the lens does not naturally develop tumors, we reasoned that lens stem cells may not be present within the capsule. We hypothesize that lens stem cells reside outside the lens capsule, in the nearby ciliary body. Our ideas challenge the existing lens biology paradigm. We begin our discussion with lens background information, in order to describe our lens stem cell hypothesis in the context of published data. Then we present the ciliary body as a possible source for lens stem cells, and conclude by comparing the ocular lens with the corneal epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.