ArticleTheoretical biology & medical modelling2007
Optimization principles of dendritic structure.
Article in Theoretical biology & medical modelling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed.
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- Models of Purkinje cell dendritic tree selection during early cerebellar development.PLoS computational biology · 2023Article
- Semi-Automated Quantitative Evaluation of Neuron Developmental Morphology In Vitro Using the Change-Point Test.Neuroinformatics · 2023Article
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
- Digital Reconstruction of the Neuro-Glia-Vascular Architecture.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Dendritic normalisation improves learning in sparsely connected artificial neural networks.PLoS computational biology · 2021Article
- Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers.PLoS computational biology · 2021Article
- Single-neuron dynamical effects of dendritic pruning implicated in aging and neurodegeneration: towards a measure of neuronal reserve.Scientific reports · 2021Article
- Prediction of Neural Diameter From Morphology to Enable Accurate Simulation.Frontiers in neuroinformatics · 2021Article
- Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction.eLife · 2020Article
- A Systematic Evaluation of Interneuron Morphology Representations for Cell Type Discrimination.Neuroinformatics · 2020Article
- Flexible neural connectivity under constraints on total connection strength.PLoS computational biology · 2020Article
- Exact solutions to cable equations in branching neurons with tapering dendrites.Journal of mathematical neuroscience · 2020Article
6 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
backgroundDendrites are the most conspicuous feature of neurons. However, the principles determining their structure are poorly understood. By employing cable theory and, for the first time, graph theory, we describe dendritic anatomy solely on the basis of optimizing synaptic efficacy with minimal resources.
resultsWe show that dendritic branching topology can be well described by minimizing the path length from the neuron's dendritic root to each of its synaptic inputs while constraining the total length of wiring. Tapering of diameter toward the dendrite tip--a feature of many neurons--optimizes charge transfer from all dendritic synapses to the dendritic root while housekeeping the amount of dendrite volume. As an example, we show how dendrites of fly neurons can be closely reconstructed based on these two principles alone.
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