ArticlePLoS genetics2007
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 12 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 12 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Association of taller stature with lower cardiovascular disease mortality in Asian people: a systematic review.Journal of physiological anthropology · 2019Pooled it
- Pooled it
- Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.Human molecular genetics · 2015Pooled it
- Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.International journal of epidemiology · 2012Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Evidence of inbreeding depression on human height.PLoS genetics · 2012Pooled it
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.PLoS genetics · 2011Pooled it
- Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.American journal of human genetics · 2011Pooled it
- Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.Human molecular genetics · 2009Pooled it
- Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.PLoS genetics · 2009Pooled it
- Identification of ten loci associated with height highlights new biological pathways in human growth.Nature genetics · 2008Pooled it
- Common variants in the GDF5-UQCC region are associated with variation in human height.Nature genetics · 2008Pooled it
- Computationally efficient methods for estimating phenome-wide coheritability of multi-type phenotypes using biobank data.Communications biology · 2025Article
- Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Standing tall or falling short: A narrative review of height dissatisfaction and psychological outcomes.PLOS mental health · 2025Review
- Human height: a model common complex trait.Annals of human biology · 2023Review
- Estimation of Causal Effect of Age at Menarche on Pubertal Height Growth Using Mendelian Randomization.Genes · 2022Article
- Challenges and future directions for studying effects of host genetics on the gut microbiome.Nature genetics · 2022Review
- Masticatory muscle function affects the pathological conditions of dentofacial deformities.The Japanese dental science review · 2020Review
- Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health.Frontiers in endocrinology · 2020Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 8 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort differences. The GenomEUtwin (http://www.genomeutwin.org) consortium consists of eight twin cohorts (Australian, Danish, Dutch, Finnish, Italian, Norwegian, Swedish, and United Kingdom) with the total resource of hundreds of thousands of twin pairs. We performed quantitative trait locus (QTL) analysis of one of the most heritable human complex traits, adult stature (body height) using genome-wide scans performed for 3,817 families (8,450 individuals) derived from twin cohorts from Australia, Denmark, Finland, Netherlands, Sweden, and United Kingdom with an approximate ten-centimorgan microsatellite marker map. The marker maps for different studies differed and they were combined and related to the sequence positions using software developed by us, which is publicly available (https://apps.bioinfo.helsinki.fi/software/cartographer.aspx). Variance component linkage analysis was performed with age, sex, and country of origin as covariates. The covariate adjusted heritability was 81% for stature in the pooled dataset. We found evidence for a major QTL for human stature on 8q21.3 (multipoint logarithm of the odds 3.28), and suggestive evidence for loci on Chromosomes X, 7, and 20. Some evidence of sex heterogeneity was found, however, no obvious female-specific QTLs emerged. Several cohorts contributed to the identified loci, suggesting an evolutionarily old genetic variant having effects on stature in European-based populations. To facilitate the genetic studies of stature we have also set up a website that lists all stature genome scans published and their most significant loci (http://www.genomeutwin.org/stature_gene_map.htm).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.