Evidence map›Paper›PMID 17559071›Full record

ReviewJournal of cellular physiology2007

Liver regeneration.

George K Michalopoulos

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of cellular physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07329296 (The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation), which is not on this map. Cited by 742 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
742citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07329296 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study

Typeobservational_patient_registrySponsorErasmus Medical CenterRan2026 to 2027Enrolled90ConditionsLiving Donor Liver TransplantationArmsLiving liver donation
3 · Its place in the literature

Who cites it

742 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness.Genes to cells : devoted to molecular & cellular mechanisms · 2026
    Article
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682 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

George K MichalopoulosDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. michalopoulosgk@upmc.edu

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
HGF IN LIVER REGENERATION, DIFFERENTIATION AND NEOPLASIAR01CA035373 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHALOPOULOS, GEORGE K · 1985 to 2011
$3.8M
HGF and Signaling Pathways in Hepatic Tissue AssemblyR01CA103958 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHALOPOULOS, GEORGE K · 2004 to 2014
$2.9M
NCATS NIH HHS UL1 TR000005NCI NIH HHS CA035373NCI NIH HHS CA103958NCI NIH HHS R01 CA035373NCI NIH HHS R01 CA103958
6 · The paper itself

Abstract

Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.

Indexed as

AnimalsEpithelial CellsHemodynamicsHepatectomyHepatocytesHumansInterleukin-6LiverLiver RegenerationMitosisSignal TransductionStem CellsTransforming Growth Factor beta1Interleukin-6Transforming Growth Factor beta1

Identifiers

PMID17559071
PMCPMC2701258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.