ReviewAnnals of medicine2007
Molecular genetics of congenital diaphragmatic defects.
Review in Annals of medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Increased burden of de novo predicted deleterious variants in complex congenital diaphragmatic hernia.Human molecular genetics · 2015Trial
- Profiling circular RNAs in amniotic fluid and fetal lungs from congenital diaphragmatic hernia cases: insights into potential prognostic and diagnostic applications.Pediatric surgery international · 2026Article
- Unexpected diagnosis: a case of incidental congenital diaphragmatic hernia.Oxford medical case reports · 2025Article
- Congenital diaphragmatic hernia.Nature reviews. Disease primers · 2022Review
- Genetically Modified Mouse Models of Congenital Diaphragmatic Hernia: Opportunities and Limitations for Studying Altered Lung Development.Frontiers in pediatrics · 2022Review
- Cellular, molecular, and metabolic aspects of developing lungs in congenital diaphragmatic hernia.Frontiers in pediatrics · 2022Review
- Robotic repair of incarcerated morgagni hernia in an adult on the acute care surgery serviceRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
- Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue.Diagnostics (Basel, Switzerland) · 2021Article
- The influence of genetics in congenital diaphragmatic hernia.Seminars in perinatology · 2020Review
- De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders.PLoS genetics · 2018Observational
- Hernia of Morgagni in the Elderly: A Case Report.Cureus · 2017Article
- Minimally invasive surgery for diaphragmatic diseases in neonates and infants.Surgery today · 2016Review
- Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.The Journal of clinical investigation · 2014Article
- MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.Human molecular genetics · 2013Article
- Laparoscopic transperitoneal repair of pediatric diaphragm eventration using an endostapler device.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2013Article
- A family-based paradigm to identify candidate chromosomal regions for isolated congenital diaphragmatic hernia.American journal of medical genetics. Part A · 2012Article
- Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?International journal of pediatric endocrinology · 2012Article
- Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Congenital diaphragmatic hernia.Orphanet journal of rare diseases · 2012Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Congenital diaphragmatic hernia (CDH) is a severe birth defect that is accompanied by malformations of the lung, heart, testis, and other organs. Patients with CDH may have any combination of these extradiaphragmatic defects, suggesting that CDH is often a manifestation of a global embryopathy. This review highlights recent advances in human and mouse genetics that have led to the identification of genes involved in CDH. These include genes for transcription factors, molecules involved in cell migration, and extracellular matrix components. The expression patterns of these genes in the developing embryo suggest that mesenchymal cell function is compromised in the diaphragm and other affected organs in patients with CDH. We discuss potential mechanisms underlying the seemingly random combination of diaphragmatic, pulmonary, cardiovascular, and gonadal defects in these patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.