ReviewThe Journal of membrane biology2006
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering.
Review in The Journal of membrane biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of Oxaliplatin on Facial Sensitivity to Cool Temperatures and TRPM8 Expressing Trigeminal Ganglion Neurons in Mice.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice.JACC. Basic to translational science · 2018Article
- TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome.The Journal of physiology · 2018Article
- Effects of acidic pH on voltage-gated ion channels in rat trigeminal mesencephalic nucleus neurons.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology.Stem cells (Dayton, Ohio) · 2016Article
- Electrical resonance with voltage-gated ion channels: perspectives from biophysical mechanisms and neural electrophysiology.Acta pharmacologica Sinica · 2016Review
- Changes in hyperpolarization-activated cyclic nucleotide-gated channel expression and activity in bladder interstitial cells of Cajal from rats with detrusor overactivity.International urogynecology journal · 2015Article
- Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells.BioMed research international · 2013Review
- Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.Circulation · 2012Article
- Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned?Gene therapy · 2012Review
- HCN channels in the heart: lessons from mouse mutants.British journal of pharmacology · 2012Review
- The Role of HCN Channels on Membrane Excitability in the Nervous System.Journal of signal transduction · 2012Article
- Human pluripotent stem cell-based approaches for myocardial repair: from the electrophysiological perspective.Molecular pharmaceutics · 2011Review
- The road to biological pacing.Nature reviews. Cardiology · 2011Review
- Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels.Pflugers Archiv : European journal of physiology · 2009Article
- Synergistic effects of inward rectifier (I) and pacemaker (I) currents on the induction of bioengineered cardiac automaticity.Journal of cardiovascular electrophysiology · 2009Article
- Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- State-dependent accessibility of the P-S6 linker of pacemaker (HCN) channels supports a dynamic pore-to-gate coupling model.The Journal of membrane biology · 2009Article
- Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state.Biochemical and biophysical research communications · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The depolarizing membrane ionic current I(h) (also known as I(f), "f" for funny), encoded by the hyperpolarization-activated cyclic-nucleotide-modulated (HCN1-4) channel gene family, was first discovered in the heart over 25 years ago. Later, I(h) was also found in neurons, retina, and taste buds. HCN channels structurally resemble voltage-gated K(+) (Kv) channels but the molecular features underlying their opposite gating behaviors (activation by hyperpolarization rather than depolarization) and non-selective permeation profiles (> or =25 times less selective for K(+) than Kv channels) remain largely unknown. Although I(h) has been functionally linked to biological processes from the autonomous beating of the heart to pain transmission, the underlying mechanistic actions remain largely inferential and, indeed, somewhat controversial due to the slow kinetics and negative operating voltage range relative to those of the bioelectrical events involved (e.g., cardiac pacing). This article reviews the current state of our knowledge in the structure-function properties of HCN channels in the context of their physiological functions and potential HCN-based therapies via bioengineering.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.