ArticleIntensive care medicine2007
Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- Muramyl dipeptide-based analogs as potential anticancer compounds: Strategies to improve selectivity, biocompatibility, and efficiency.Frontiers in oncology · 2022Review
- Ileocolonic Healing After Extended Small Bowel Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing and Postoperative Outcome.Inflammatory bowel diseases · 2021Article
- Neovascular glaucoma regulation by arylsulfonyl indoline-benzamide (ASIB) through targeting NF-kB signalling pathway.3 Biotech · 2019Article
- NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients.Scientific reports · 2017Article
- Alterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.International journal of colorectal disease · 2016Article
- Saikosaponin A protects against experimental sepsis via inhibition of NOD2-mediated NF-κB activation.Experimental and therapeutic medicine · 2015Article
- Pattern recognition receptors and the inflammasome in kidney disease.Nature reviews. Nephrology · 2014Review
- Two patients with intestinal failure requiring home parenteral nutrition, a NOD2 mutation and tuberculous lymphadenitis.BMC gastroenterology · 2014Article
- Role of non-HLA gene polymorphisms in graft-versus-host disease.International journal of hematology · 2013Review
- Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Article
- Role of NOD2 in regulating the immune response to Aspergillus fumigatus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish.Disease models & mechanisms · 2011Article
- CARD15 mutations and perianal fistulating Crohn's disease: correlation and predictive value of antibiotic response.Digestive diseases and sciences · 2011Article
- Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation.Clinical and experimental immunology · 2008Article
- Year in review in Intensive Care Medicine, 2007. II. Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation, acute respiratory distress syndrome.Intensive care medicine · 2008Review
- Evolution of Crohn's disease-associated Nod2 mutations.Immunogenetics · 2008Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGenetic variants in the NOD2/CARD15 gene resulting in a diminished capacity to activate NF-kappaB in response to bacterial cell wall products have been associated with Crohn's disease (CD). Recently, we found an association between the variant Leu1007fsinsC of the NOD2/CARD15 gene (SNP13) and a significantly increased rate of transplant related mortality (TRM) due to intestinal and pulmonary complications in stem cell transplantation (SCT). To assess a possible contribution of variants in the NOD2/CARD15 gene to sepsis related mortality (SRM) we investigated 132 prospectively characterised, consecutive patients with sepsis. DESIGN AND PATIENTS: The three most common NOD2/CARD15 variants (Arg702Trp, Gly908Arg, and Leu1007fsinsC) were determined in 132 prospectively characterised patients with sepsis attended to three intensive care units at the University of Regensburg by Taqman PCR. NOD2/CARD15 genotype and major patients' characteristics were correlated with SRM.
resultsPatient groups with and without NOD2/CARD15 variants did not differ in their clinical characteristics such as median age, gender, reason for admission or APACHE score; however, SRM (day 30) was increased in patients with NOD2/CARD15 coding variants (42 vs. 31%) and was highest (57%) in 8 patients carrying the Leu1007fsinsC variant (p < 0.05). Multivariate analysis demonstrated the Leu1007fsinsC genetic variant as an independent risk factor for SRM.
conclusionOur findings indicate a major role of NOD2/CARD15 coding variants for SRM. This may be indicative for a role of impaired barrier function and bacterial translocation in the pathophysiology of early sepsis related death.
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