ArticleNature neuroscience2007
Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.
Article in Nature neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- The functional -1019C/G HTR1A polymorphism and mechanisms of fear.Translational psychiatry · 2014Trial
- Article
- Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep.bioRxiv : the preprint server for biology · 2025Article
- How can ethology inform the neuroscience of fear, aggression and dominance?Nature reviews. Neuroscience · 2024Review
- 5-HTBiological psychiatry · 2024Article
- Cannabidiol and brain function: current knowledge and future perspectives.Frontiers in pharmacology · 2023Review
- Neuroadaptations and TGF-β signaling: emerging role in models of neuropsychiatric disorders.Molecular psychiatry · 2022Review
- A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat.eLife · 2020Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Behavioral and structural adaptations to stress.Frontiers in neuroendocrinology · 2018Review
- mGlu1 receptor as a drug target for treatment of substance use disorders: time to gather stones together?Psychopharmacology · 2017Review
- Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cues.PLoS biology · 2017Article
- Article
- Hippocampal Processing of Ambiguity Enhances Fear Memory.Psychological science · 2017Article
- Emergence in extinction of enhanced and persistent responding to ambiguous aversive cues is associated with high MAOA activity in the prelimbic cortex.Neurobiology of stress · 2016Article
- Stress Enables Reinforcement-Elicited Serotonergic Consolidation of Fear Memory.Biological psychiatry · 2016Article
- Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells.Nature communications · 2016Article
- 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.Nature neuroscience · 2015Article
10 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Serotonin receptor 1A knockout (Htr1a(KO)) mice show increased anxiety-related behavior in tests measuring innate avoidance. Here we demonstrate that Htr1a(KO) mice show enhanced fear conditioning to ambiguous conditioned stimuli, a hallmark of human anxiety. To examine the involvement of specific forebrain circuits in this phenotype, we developed a pharmacogenetic technique for the rapid tissue- and cell type-specific silencing of neural activity in vivo. Inhibition of neurons in the central nucleus of the amygdala suppressed conditioned responses to both ambiguous and nonambiguous cues. In contrast, inhibition of hippocampal dentate gyrus granule cells selectively suppressed conditioned responses to ambiguous cues and reversed the knockout phenotype. These data demonstrate that Htr1a(KO) mice have a bias in the processing of threatening cues that is moderated by hippocampal mossy-fiber circuits, and suggest that the hippocampus is important in the response to ambiguous aversive stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.